What Is the Catalytic Mechanism of Enzymatic Histone N‐Methyl Arginine Demethylation and Can It Be Influenced by an External Electric Field?

Invited for the cover of this issue are Christo Z. Christov and co‐workers at Michigan Technological University and University of Oxford. The image depicts the effects of applying an external electric field on the demethylation of dimethylated arginine substrate by a non‐heme Fe center Histone N‐methyl arginine demethylase. Read the full text of the article at 10.1002/chem.202101174. “Combined Quantum Mechanics and Molecular Mechanics and Molecular Dynamics studies revealed the dynamics and catalytic mechanism of the demethylation of N‐methyl arginine residue histone H4 by a non‐heme Fe(II) and 2‐oxoglutarate dependent histone demethylase.” Read more about the story behind the cover in the Cover Profile and about the research itself on page 11827 ff. (DOI: 10.1002/chem.202101174).