Relationships between tibial articular cartilage, in vivo external joint moments and static alignment in end‐stage knee osteoarthritis: A micro‐CT study

Biomechanical factors (e.g., joint loading) have a significant role in the progression of osteoarthritis (OA). However, some relationships between in vivo joint loading indices and tibial cartilage thickness are conflicting. This study investigated relationships between pre‐operative in vivo externa...

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Veröffentlicht in:Journal of orthopaedic research 2022-05, Vol.40 (5), p.1125-1134
Hauptverfasser: Rapagna, Sophie, Roberts, Bryant C., Solomon, Lucian B., Reynolds, Karen J., Thewlis, Dominic, Perilli, Egon
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Sprache:eng
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Zusammenfassung:Biomechanical factors (e.g., joint loading) have a significant role in the progression of osteoarthritis (OA). However, some relationships between in vivo joint loading indices and tibial cartilage thickness are conflicting. This study investigated relationships between pre‐operative in vivo external knee joint moments, joint alignment and regional tibial cartilage thickness using micro‐CT in subjects with end‐stage knee OA. Tibial plateaus from 25 patients that underwent knee replacement for OA were micro‐CT scanned (17 µm/voxel). Prior to surgery, subjects underwent gait analysis to calculate external knee moments. The mechanical axis deviation (MAD) was obtained from pre‐operative radiographs. Cartilage thickness (Cart.Th) was analyzed from micro‐CT images, in anteromedial, anterolateral, posteromedial and posterolateral subregions of interest. Medial‐to‐lateral Cart.Th ratios were also explored. Relationships between Cart.Th and joint loading indices were examined using Pearson's correlations. Significant correlations were found between Cart.Th and joint loading indices, positive anteromedially with the first peak knee adduction moment (r = 0.55, p 
ISSN:0736-0266
1554-527X
DOI:10.1002/jor.25140