Design and Development of the First Peptide-Chelating Bisphosphane Bioconjugate from a Novel Functionalized Phosphorus(III) Hydride Synthon

Design and Development of the First Peptide-Chelating Bisphosphane Bioconjugate from a Novel Functionalized Phosphorus(III) Hydride Synthon

Remarkable oxidative stability is shown by the carboxylate‐functionalized primary bisphosphane 1. Compound 1 can be used in conjugation reactions with biomolecules for functionalization through the COOH group without prior protection of PH2 groups. A novel water‐soluble bisphosphane was obtained by...

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Veröffentlicht in:Angewandte Chemie International Edition 1999-07, Vol.38 (13-14), p.2020-2023
Hauptverfasser: Gali, Hariprasad, Karra, Srinivasa R., Reddy, V. Sreenivasa, Katti, Kattesh V.
Format: Artikel
Sprache:eng
Schlagworte:
Bioorganic chemistry
Peptide conjugates
Phosphanes
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Zusammenfassung:Remarkable oxidative stability is shown by the carboxylate‐functionalized primary bisphosphane 1. Compound 1 can be used in conjugation reactions with biomolecules for functionalization through the COOH group without prior protection of PH2 groups. A novel water‐soluble bisphosphane was obtained by reaction of the PH2 groups of 1 with formaldehyde under mild conditions.
ISSN:1433-7851
1521-3773
DOI:10.1002/(SICI)1521-3773(19990712)38:13/14<2020::AID-ANIE2020>3.0.CO;2-R