Alterations in the Gut Virome in Obesity and Type 2 Diabetes Mellitus
Obesity and type 2 diabetes mellitus (T2DM) are associated with changes in the gut bacterial composition, but little is known about the role of the viral community (virome) in disease development. This study aims to characterize the gut virome alterations in obese subjects with or without T2DM. Ther...
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| Veröffentlicht in: | Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2021-10, Vol.161 (4), p.1257-1269.e13 |
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| container_title | Gastroenterology (New York, N.Y. 1943) |
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| creator | Yang, Keli Niu, Junkun Zuo, Tao Sun, Yang Xu, Zhilu Tang, Whitney Liu, Qin Zhang, Jingwan Ng, Enders K.W. Wong, Simon K.H. Yeoh, Yun Kit Chan, Paul K.S. Chan, Francis K.L. Miao, Yinglei Ng, Siew C. |
| description | Obesity and type 2 diabetes mellitus (T2DM) are associated with changes in the gut bacterial composition, but little is known about the role of the viral community (virome) in disease development. This study aims to characterize the gut virome alterations in obese subjects with or without T2DM.
There were 128 obese subjects (body mass index ≥28 kg/m2) and 101 lean controls (body mass index ≥18.5 and |
| doi_str_mv | 10.1053/j.gastro.2021.06.056 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2545994114</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S001650852103170X</els_id><sourcerecordid>2545994114</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-1519f497dad834e53c401950de5ed9cad4cd5aba34a8efd4374985b6957790ba3</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMotn78A5Ecvew62U12NxehaK1CxYt6Ddlkqintbk2yQv-9KVWPngaG552Ph5ALBjkDUV4v83cdou_zAgqWQ5WDqA7ImImiyQBYcUjGqVSZgEaMyEkISwCQZcOOyajkrE4cjMl0sorodXR9F6jraPxAOhsifXO-X-Ou89xicHFLdWfpy3aDtKB3TrcYMdAnXK1cHMIZOVroVcDzn3pKXu-nL7cP2fx59ng7mWeG1zxmTDC54LK22jYlR1EaDkwKsCjQSqMtN1boVpdcN7iwvKy5bERbSVHXElL_lFzt5258_zlgiGrtgklH6A77IahCcCElZ4wnlO9R4_sQPC7Uxru19lvFQO0EqqXaC1Q7gQoqlQSm2OXPhqFdo_0L_RpLwM0ewPTnl0OvgnHYGbTOo4nK9u7_Dd9fOYJn</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2545994114</pqid></control><display><type>article</type><title>Alterations in the Gut Virome in Obesity and Type 2 Diabetes Mellitus</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>Alma/SFX Local Collection</source><creator>Yang, Keli ; Niu, Junkun ; Zuo, Tao ; Sun, Yang ; Xu, Zhilu ; Tang, Whitney ; Liu, Qin ; Zhang, Jingwan ; Ng, Enders K.W. ; Wong, Simon K.H. ; Yeoh, Yun Kit ; Chan, Paul K.S. ; Chan, Francis K.L. ; Miao, Yinglei ; Ng, Siew C.</creator><creatorcontrib>Yang, Keli ; Niu, Junkun ; Zuo, Tao ; Sun, Yang ; Xu, Zhilu ; Tang, Whitney ; Liu, Qin ; Zhang, Jingwan ; Ng, Enders K.W. ; Wong, Simon K.H. ; Yeoh, Yun Kit ; Chan, Paul K.S. ; Chan, Francis K.L. ; Miao, Yinglei ; Ng, Siew C.</creatorcontrib><description>Obesity and type 2 diabetes mellitus (T2DM) are associated with changes in the gut bacterial composition, but little is known about the role of the viral community (virome) in disease development. This study aims to characterize the gut virome alterations in obese subjects with or without T2DM.
There were 128 obese subjects (body mass index ≥28 kg/m2) and 101 lean controls (body mass index ≥18.5 and <23 kg/m2) recruited from 2 regions in China (Hong Kong and Kunming). Fecal virome and bacteriome were profiled by shotgun metagenomic sequencing. Gut virome, bacteriome, and viral-bacterial correlations were compared between obese subjects and lean controls.
Obese subjects, especially those with T2DM (ObT2), had a decreased gut viral richness and diversity compared with lean controls in the Hong Kong cohort (P < .05), while no significant differences were observed in the Kunming cohort. Eleven viruses, including Escherichia phage, Geobacillus phage, and Lactobacillus phage were enriched in obese subjects (q < .1). Besides, 17 differentially abundant viruses were identified between ObT2 and lean controls (q < .1). Further ecologic analysis revealed that intensive transkingdom correlations between viruses and bacteria observed in lean controls were significantly decreased in ObT2 subjects (P < .001).
Obesity is characterized by altered viral taxonomic composition and weakened viral-bacterial correlations compared with lean controls. Obesity accompanied with T2DM may aggravate the obesity-associated virus signatures, signifying that the gut virome may play an important role in the development of obesity and T2DM. Geographic factors also contributed to the variations of gut virome in obesity and T2DM.
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Obese individuals have a dysbiotic gut virome, and type 2 diabetes mellitus further aggravates such dysbiosis.</description><identifier>ISSN: 0016-5085</identifier><identifier>EISSN: 1528-0012</identifier><identifier>DOI: 10.1053/j.gastro.2021.06.056</identifier><identifier>PMID: 34175280</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Case-Control Studies ; Diabetes Mellitus, Type 2 - diagnosis ; Diabetes Mellitus, Type 2 - microbiology ; Diabetes Mellitus, Type 2 - virology ; Dysbiosis ; Feces - microbiology ; Feces - virology ; Female ; Gastrointestinal Microbiome ; Hong Kong ; Host-Pathogen Interactions ; Humans ; Intestines - microbiology ; Intestines - virology ; Male ; Metabolic Diseases ; Metagenome ; Metagenomics ; Microbiota ; Middle Aged ; Obesity - diagnosis ; Obesity - microbiology ; Obesity - virology ; Virome - genetics ; Weight ; Young Adult</subject><ispartof>Gastroenterology (New York, N.Y. 1943), 2021-10, Vol.161 (4), p.1257-1269.e13</ispartof><rights>2021 AGA Institute</rights><rights>Copyright © 2021 AGA Institute. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-1519f497dad834e53c401950de5ed9cad4cd5aba34a8efd4374985b6957790ba3</citedby><cites>FETCH-LOGICAL-c474t-1519f497dad834e53c401950de5ed9cad4cd5aba34a8efd4374985b6957790ba3</cites><orcidid>0000-0002-6850-4454</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1053/j.gastro.2021.06.056$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34175280$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Keli</creatorcontrib><creatorcontrib>Niu, Junkun</creatorcontrib><creatorcontrib>Zuo, Tao</creatorcontrib><creatorcontrib>Sun, Yang</creatorcontrib><creatorcontrib>Xu, Zhilu</creatorcontrib><creatorcontrib>Tang, Whitney</creatorcontrib><creatorcontrib>Liu, Qin</creatorcontrib><creatorcontrib>Zhang, Jingwan</creatorcontrib><creatorcontrib>Ng, Enders K.W.</creatorcontrib><creatorcontrib>Wong, Simon K.H.</creatorcontrib><creatorcontrib>Yeoh, Yun Kit</creatorcontrib><creatorcontrib>Chan, Paul K.S.</creatorcontrib><creatorcontrib>Chan, Francis K.L.</creatorcontrib><creatorcontrib>Miao, Yinglei</creatorcontrib><creatorcontrib>Ng, Siew C.</creatorcontrib><title>Alterations in the Gut Virome in Obesity and Type 2 Diabetes Mellitus</title><title>Gastroenterology (New York, N.Y. 1943)</title><addtitle>Gastroenterology</addtitle><description>Obesity and type 2 diabetes mellitus (T2DM) are associated with changes in the gut bacterial composition, but little is known about the role of the viral community (virome) in disease development. This study aims to characterize the gut virome alterations in obese subjects with or without T2DM.
There were 128 obese subjects (body mass index ≥28 kg/m2) and 101 lean controls (body mass index ≥18.5 and <23 kg/m2) recruited from 2 regions in China (Hong Kong and Kunming). Fecal virome and bacteriome were profiled by shotgun metagenomic sequencing. Gut virome, bacteriome, and viral-bacterial correlations were compared between obese subjects and lean controls.
Obese subjects, especially those with T2DM (ObT2), had a decreased gut viral richness and diversity compared with lean controls in the Hong Kong cohort (P < .05), while no significant differences were observed in the Kunming cohort. Eleven viruses, including Escherichia phage, Geobacillus phage, and Lactobacillus phage were enriched in obese subjects (q < .1). Besides, 17 differentially abundant viruses were identified between ObT2 and lean controls (q < .1). Further ecologic analysis revealed that intensive transkingdom correlations between viruses and bacteria observed in lean controls were significantly decreased in ObT2 subjects (P < .001).
Obesity is characterized by altered viral taxonomic composition and weakened viral-bacterial correlations compared with lean controls. Obesity accompanied with T2DM may aggravate the obesity-associated virus signatures, signifying that the gut virome may play an important role in the development of obesity and T2DM. Geographic factors also contributed to the variations of gut virome in obesity and T2DM.
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Obese individuals have a dysbiotic gut virome, and type 2 diabetes mellitus further aggravates such dysbiosis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Case-Control Studies</subject><subject>Diabetes Mellitus, Type 2 - diagnosis</subject><subject>Diabetes Mellitus, Type 2 - microbiology</subject><subject>Diabetes Mellitus, Type 2 - virology</subject><subject>Dysbiosis</subject><subject>Feces - microbiology</subject><subject>Feces - virology</subject><subject>Female</subject><subject>Gastrointestinal Microbiome</subject><subject>Hong Kong</subject><subject>Host-Pathogen Interactions</subject><subject>Humans</subject><subject>Intestines - microbiology</subject><subject>Intestines - virology</subject><subject>Male</subject><subject>Metabolic Diseases</subject><subject>Metagenome</subject><subject>Metagenomics</subject><subject>Microbiota</subject><subject>Middle Aged</subject><subject>Obesity - diagnosis</subject><subject>Obesity - microbiology</subject><subject>Obesity - virology</subject><subject>Virome - genetics</subject><subject>Weight</subject><subject>Young Adult</subject><issn>0016-5085</issn><issn>1528-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotn78A5Ecvew62U12NxehaK1CxYt6Ddlkqintbk2yQv-9KVWPngaG552Ph5ALBjkDUV4v83cdou_zAgqWQ5WDqA7ImImiyQBYcUjGqVSZgEaMyEkISwCQZcOOyajkrE4cjMl0sorodXR9F6jraPxAOhsifXO-X-Ou89xicHFLdWfpy3aDtKB3TrcYMdAnXK1cHMIZOVroVcDzn3pKXu-nL7cP2fx59ng7mWeG1zxmTDC54LK22jYlR1EaDkwKsCjQSqMtN1boVpdcN7iwvKy5bERbSVHXElL_lFzt5258_zlgiGrtgklH6A77IahCcCElZ4wnlO9R4_sQPC7Uxru19lvFQO0EqqXaC1Q7gQoqlQSm2OXPhqFdo_0L_RpLwM0ewPTnl0OvgnHYGbTOo4nK9u7_Dd9fOYJn</recordid><startdate>202110</startdate><enddate>202110</enddate><creator>Yang, Keli</creator><creator>Niu, Junkun</creator><creator>Zuo, Tao</creator><creator>Sun, Yang</creator><creator>Xu, Zhilu</creator><creator>Tang, Whitney</creator><creator>Liu, Qin</creator><creator>Zhang, Jingwan</creator><creator>Ng, Enders K.W.</creator><creator>Wong, Simon K.H.</creator><creator>Yeoh, Yun Kit</creator><creator>Chan, Paul K.S.</creator><creator>Chan, Francis K.L.</creator><creator>Miao, Yinglei</creator><creator>Ng, Siew C.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6850-4454</orcidid></search><sort><creationdate>202110</creationdate><title>Alterations in the Gut Virome in Obesity and Type 2 Diabetes Mellitus</title><author>Yang, Keli ; Niu, Junkun ; Zuo, Tao ; Sun, Yang ; Xu, Zhilu ; Tang, Whitney ; Liu, Qin ; Zhang, Jingwan ; Ng, Enders K.W. ; Wong, Simon K.H. ; Yeoh, Yun Kit ; Chan, Paul K.S. ; Chan, Francis K.L. ; Miao, Yinglei ; Ng, Siew C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-1519f497dad834e53c401950de5ed9cad4cd5aba34a8efd4374985b6957790ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Case-Control Studies</topic><topic>Diabetes Mellitus, Type 2 - diagnosis</topic><topic>Diabetes Mellitus, Type 2 - microbiology</topic><topic>Diabetes Mellitus, Type 2 - virology</topic><topic>Dysbiosis</topic><topic>Feces - microbiology</topic><topic>Feces - virology</topic><topic>Female</topic><topic>Gastrointestinal Microbiome</topic><topic>Hong Kong</topic><topic>Host-Pathogen Interactions</topic><topic>Humans</topic><topic>Intestines - microbiology</topic><topic>Intestines - virology</topic><topic>Male</topic><topic>Metabolic Diseases</topic><topic>Metagenome</topic><topic>Metagenomics</topic><topic>Microbiota</topic><topic>Middle Aged</topic><topic>Obesity - diagnosis</topic><topic>Obesity - microbiology</topic><topic>Obesity - virology</topic><topic>Virome - genetics</topic><topic>Weight</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Keli</creatorcontrib><creatorcontrib>Niu, Junkun</creatorcontrib><creatorcontrib>Zuo, Tao</creatorcontrib><creatorcontrib>Sun, Yang</creatorcontrib><creatorcontrib>Xu, Zhilu</creatorcontrib><creatorcontrib>Tang, Whitney</creatorcontrib><creatorcontrib>Liu, Qin</creatorcontrib><creatorcontrib>Zhang, Jingwan</creatorcontrib><creatorcontrib>Ng, Enders K.W.</creatorcontrib><creatorcontrib>Wong, Simon K.H.</creatorcontrib><creatorcontrib>Yeoh, Yun Kit</creatorcontrib><creatorcontrib>Chan, Paul K.S.</creatorcontrib><creatorcontrib>Chan, Francis K.L.</creatorcontrib><creatorcontrib>Miao, Yinglei</creatorcontrib><creatorcontrib>Ng, Siew C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Keli</au><au>Niu, Junkun</au><au>Zuo, Tao</au><au>Sun, Yang</au><au>Xu, Zhilu</au><au>Tang, Whitney</au><au>Liu, Qin</au><au>Zhang, Jingwan</au><au>Ng, Enders K.W.</au><au>Wong, Simon K.H.</au><au>Yeoh, Yun Kit</au><au>Chan, Paul K.S.</au><au>Chan, Francis K.L.</au><au>Miao, Yinglei</au><au>Ng, Siew C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alterations in the Gut Virome in Obesity and Type 2 Diabetes Mellitus</atitle><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle><addtitle>Gastroenterology</addtitle><date>2021-10</date><risdate>2021</risdate><volume>161</volume><issue>4</issue><spage>1257</spage><epage>1269.e13</epage><pages>1257-1269.e13</pages><issn>0016-5085</issn><eissn>1528-0012</eissn><abstract>Obesity and type 2 diabetes mellitus (T2DM) are associated with changes in the gut bacterial composition, but little is known about the role of the viral community (virome) in disease development. This study aims to characterize the gut virome alterations in obese subjects with or without T2DM.
There were 128 obese subjects (body mass index ≥28 kg/m2) and 101 lean controls (body mass index ≥18.5 and <23 kg/m2) recruited from 2 regions in China (Hong Kong and Kunming). Fecal virome and bacteriome were profiled by shotgun metagenomic sequencing. Gut virome, bacteriome, and viral-bacterial correlations were compared between obese subjects and lean controls.
Obese subjects, especially those with T2DM (ObT2), had a decreased gut viral richness and diversity compared with lean controls in the Hong Kong cohort (P < .05), while no significant differences were observed in the Kunming cohort. Eleven viruses, including Escherichia phage, Geobacillus phage, and Lactobacillus phage were enriched in obese subjects (q < .1). Besides, 17 differentially abundant viruses were identified between ObT2 and lean controls (q < .1). Further ecologic analysis revealed that intensive transkingdom correlations between viruses and bacteria observed in lean controls were significantly decreased in ObT2 subjects (P < .001).
Obesity is characterized by altered viral taxonomic composition and weakened viral-bacterial correlations compared with lean controls. Obesity accompanied with T2DM may aggravate the obesity-associated virus signatures, signifying that the gut virome may play an important role in the development of obesity and T2DM. Geographic factors also contributed to the variations of gut virome in obesity and T2DM.
[Display omitted]
Obese individuals have a dysbiotic gut virome, and type 2 diabetes mellitus further aggravates such dysbiosis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>34175280</pmid><doi>10.1053/j.gastro.2021.06.056</doi><orcidid>https://orcid.org/0000-0002-6850-4454</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Gastroenterology (New York, N.Y. 1943), 2021-10, Vol.161 (4), p.1257-1269.e13 |
| issn | 0016-5085 1528-0012 |
| language | eng |
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| subjects | Adolescent Adult Aged Case-Control Studies Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - microbiology Diabetes Mellitus, Type 2 - virology Dysbiosis Feces - microbiology Feces - virology Female Gastrointestinal Microbiome Hong Kong Host-Pathogen Interactions Humans Intestines - microbiology Intestines - virology Male Metabolic Diseases Metagenome Metagenomics Microbiota Middle Aged Obesity - diagnosis Obesity - microbiology Obesity - virology Virome - genetics Weight Young Adult |
| title | Alterations in the Gut Virome in Obesity and Type 2 Diabetes Mellitus |
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