Alterations in the Gut Virome in Obesity and Type 2 Diabetes Mellitus

Alterations in the Gut Virome in Obesity and Type 2 Diabetes Mellitus

Obesity and type 2 diabetes mellitus (T2DM) are associated with changes in the gut bacterial composition, but little is known about the role of the viral community (virome) in disease development. This study aims to characterize the gut virome alterations in obese subjects with or without T2DM. Ther...

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Veröffentlicht in:Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2021-10, Vol.161 (4), p.1257-1269.e13
Hauptverfasser: Yang, Keli, Niu, Junkun, Zuo, Tao, Sun, Yang, Xu, Zhilu, Tang, Whitney, Liu, Qin, Zhang, Jingwan, Ng, Enders K.W., Wong, Simon K.H., Yeoh, Yun Kit, Chan, Paul K.S., Chan, Francis K.L., Miao, Yinglei, Ng, Siew C.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Aged
Case-Control Studies
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - microbiology
Diabetes Mellitus, Type 2 - virology
Dysbiosis
Feces - microbiology
Feces - virology
Female
Gastrointestinal Microbiome
Hong Kong
Host-Pathogen Interactions
Humans
Intestines - microbiology
Intestines - virology
Male
Metabolic Diseases
Metagenome
Metagenomics
Microbiota
Middle Aged
Obesity - diagnosis
Obesity - microbiology
Obesity - virology
Virome - genetics
Weight
Young Adult
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Beschreibung
Zusammenfassung:Obesity and type 2 diabetes mellitus (T2DM) are associated with changes in the gut bacterial composition, but little is known about the role of the viral community (virome) in disease development. This study aims to characterize the gut virome alterations in obese subjects with or without T2DM. There were 128 obese subjects (body mass index ≥28 kg/m2) and 101 lean controls (body mass index ≥18.5 and
ISSN:0016-5085
1528-0012
DOI:10.1053/j.gastro.2021.06.056