Facile Approach to C‐Glucosides by Using a Protecting‐Group‐Free Hiyama Cross‐Coupling Reaction: High‐Yielding Dapagliflozin Synthesis

Invited for the cover of this issue is Kamil Parkan and co‐workers at University of Chemistry and Technology and Institute of Organic Chemistry and Biochemistry, Prague. The cover graphic depicts a schematic representation of the assembly of aryl‐C‐glycosides based on a protecting‐group‐free Hiyama reaction. Read the full text of the article at 10.1002/chem.202101052. “This work represents another step in the effort to use glycals (1,2‐unsaturated derivatives of carbohydrates) as donor synthons for transition metal‐catalyzed arylation reactions. We have employed a novel 1‐silyl derivative of d‐glucal, which was obtained as a bench‐stable solid and could therefore be used conveniently.” Read more about the story behind the cover in the Cover Profile and about the research itself on page 10583 ff. (DOI: 10.1002/chem.202101052).