A simple method for estimating dermal absorption of chemicals in water

A semiempirical mathematical model is proposed for estimating the dermal absorption of chemicals from dilute aqueous solutions, such as bath water. Absorption depends on the concentration of the chemical in water, the area of skin exposed, the time of exposure, and a permeation coefficient that depe...

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Veröffentlicht in:	Chemosphere (Oxford) 1989, Vol.19 (12), p.1989-2001
Hauptverfasser:	Brown, Stephen L., Rossi, James E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Biological and medical sciences chemical variables measurement chemicals dermal dermatology dilute aqueous solutions Environmental pollutants toxicology mathematical models Medical sciences risk assessment skin toxicity Toxicology Water
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Beschreibung
Zusammenfassung:	A semiempirical mathematical model is proposed for estimating the dermal absorption of chemicals from dilute aqueous solutions, such as bath water. Absorption depends on the concentration of the chemical in water, the area of skin exposed, the time of exposure, and a permeation coefficient that depends importantly on the relative solubility of the material in lipids and water, among other factors not so easily modeled.
ISSN:	0045-6535 1879-1298
DOI:	10.1016/0045-6535(89)90022-2