Transmembrane Protease TMPRSS4 Promotes the Formation and Development of Mismatch Repair Deficient Colon Cancer Liver Metastasis
We studied metastasis-promoting effect of transmembrane protease TMPRSS4 on mismatch repair (MMR)-deficient colorectal cancer liver metastasis in BALB/c nude mouse model. Histomorphological and histopathological studies showed that the number of liver metastases in the study group were significantly...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2021-05, Vol.171 (2), p.242-246 |
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| creator | Yang, Y. S. Wen, D. Zhao, X. F. |
| description | We studied metastasis-promoting effect of transmembrane protease TMPRSS4 on mismatch repair (MMR)-deficient colorectal cancer liver metastasis in BALB/c nude mouse model. Histomorphological and histopathological studies showed that the number of liver metastases in the study group were significantly higher than that in the control group (
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| doi_str_mv | 10.1007/s10517-021-05203-6 |
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p
<0.05). The expression of TMPRSS4 mRNA and protein in the study group were obviously higher than in the control group (
p
<0.05). These findings suggest that TMPRSS4 possesses a metastasis-promoting effect and its low expression can effectively block the progression of MMR-deficient colon cancer liver metastasis.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-021-05203-6</identifier><identifier>PMID: 34173918</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Analysis ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Brain Neoplasms - complications ; Brain Neoplasms - genetics ; Brain Neoplasms - pathology ; Cell Biology ; Cell Movement - genetics ; Cell Transformation, Neoplastic - genetics ; Colon cancer ; Colonic Neoplasms - genetics ; Colonic Neoplasms - pathology ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - complications ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - pathology ; Development and progression ; Disease Progression ; DNA Mismatch Repair - genetics ; Female ; Gene expression ; Gene Expression Regulation, Neoplastic ; Humans ; Internal Medicine ; Laboratory Medicine ; Liver ; Liver cancer ; Liver Neoplasms - genetics ; Liver Neoplasms - secondary ; Membrane Proteins - genetics ; Membrane Proteins - physiology ; Metastases ; Metastasis ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Mismatch repair ; mRNA ; Neoplastic Syndromes, Hereditary - complications ; Neoplastic Syndromes, Hereditary - genetics ; Neoplastic Syndromes, Hereditary - pathology ; Oncology ; Pathology ; Proteases ; Proteinase ; RNA ; Serine Endopeptidases - genetics ; Serine Endopeptidases - physiology ; Tumor Cells, Cultured</subject><ispartof>Bulletin of experimental biology and medicine, 2021-05, Vol.171 (2), p.242-246</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c571t-225a80df124df4469e74eb0c3c25ac968bf582ca37bfe89f475f2795810778963</citedby><cites>FETCH-LOGICAL-c571t-225a80df124df4469e74eb0c3c25ac968bf582ca37bfe89f475f2795810778963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-021-05203-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-021-05203-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34173918$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Y. S.</creatorcontrib><creatorcontrib>Wen, D.</creatorcontrib><creatorcontrib>Zhao, X. F.</creatorcontrib><title>Transmembrane Protease TMPRSS4 Promotes the Formation and Development of Mismatch Repair Deficient Colon Cancer Liver Metastasis</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>We studied metastasis-promoting effect of transmembrane protease TMPRSS4 on mismatch repair (MMR)-deficient colorectal cancer liver metastasis in BALB/c nude mouse model. Histomorphological and histopathological studies showed that the number of liver metastases in the study group were significantly higher than that in the control group (
p
<0.05). The expression of TMPRSS4 mRNA and protein in the study group were obviously higher than in the control group (
p
<0.05). These findings suggest that TMPRSS4 possesses a metastasis-promoting effect and its low expression can effectively block the progression of MMR-deficient colon cancer liver metastasis.</description><subject>Analysis</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain Neoplasms - complications</subject><subject>Brain Neoplasms - genetics</subject><subject>Brain Neoplasms - pathology</subject><subject>Cell Biology</subject><subject>Cell Movement - genetics</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Colon cancer</subject><subject>Colonic Neoplasms - genetics</subject><subject>Colonic Neoplasms - pathology</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - complications</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Development and progression</subject><subject>Disease Progression</subject><subject>DNA Mismatch Repair - genetics</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - secondary</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - physiology</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Mismatch repair</subject><subject>mRNA</subject><subject>Neoplastic Syndromes, Hereditary - complications</subject><subject>Neoplastic Syndromes, Hereditary - genetics</subject><subject>Neoplastic Syndromes, Hereditary - pathology</subject><subject>Oncology</subject><subject>Pathology</subject><subject>Proteases</subject><subject>Proteinase</subject><subject>RNA</subject><subject>Serine Endopeptidases - genetics</subject><subject>Serine Endopeptidases - physiology</subject><subject>Tumor Cells, Cultured</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkl9v0zAUxS0EYqXwBXhAkZAQLxn-GzuPU8cAqRXTVp4tx71ePSVxsZNJvPHRceiADqEKJYqVe373xLk-CL0k-JRgLN8lggWRJaakxIJiVlaP0IwIyUpFKXmMZjhTJVdKnaBnKd1Or7giT9EJ40SymqgZ-r6Opk8ddE1eobiMYQCToFivLq-ur_lU6HIpFcMWiosQOzP40Bem3xTncAdt2HXQD0VwxcqnLNptcQU742OWnbd-EhehzS0L01uIxdLf5ecKBpPy7dNz9MSZNsGL-3WOvly8Xy8-lsvPHz4tzpalFZIMJaXCKLxxhPKN47yqQXJosGU2C7auVOOEotYw2ThQteNSOCproQiWUtUVm6O3e99dDF9HSIPufLLQtvm3w5g0FVxUWFVKZfT1X-htGGOfdzdRFcdUHlI3pgXtexeGaOxkqs8ko5wRztlRqlKkyvvM2Byd_oPK1wY6b0OfR5nrD2z_q-HwC28OGrZg2mGbQjtOp5keOh8FDx3pHrQxpBTB6V30nYnfNMF6yqfe51PnfOqf-dTTKby6H-3YdLD53fIrkBlgeyBlqb-B-Gf2R2x_AIY16ts</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Yang, Y. 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F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c571t-225a80df124df4469e74eb0c3c25ac968bf582ca37bfe89f475f2795810778963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Analysis</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain Neoplasms - complications</topic><topic>Brain Neoplasms - genetics</topic><topic>Brain Neoplasms - pathology</topic><topic>Cell Biology</topic><topic>Cell Movement - genetics</topic><topic>Cell Transformation, Neoplastic - genetics</topic><topic>Colon cancer</topic><topic>Colonic Neoplasms - genetics</topic><topic>Colonic Neoplasms - pathology</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - complications</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Development and progression</topic><topic>Disease Progression</topic><topic>DNA Mismatch Repair - genetics</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Laboratory Medicine</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - genetics</topic><topic>Liver Neoplasms - secondary</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - physiology</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>Mismatch repair</topic><topic>mRNA</topic><topic>Neoplastic Syndromes, Hereditary - complications</topic><topic>Neoplastic Syndromes, Hereditary - genetics</topic><topic>Neoplastic Syndromes, Hereditary - pathology</topic><topic>Oncology</topic><topic>Pathology</topic><topic>Proteases</topic><topic>Proteinase</topic><topic>RNA</topic><topic>Serine Endopeptidases - genetics</topic><topic>Serine Endopeptidases - physiology</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Y. 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S.</au><au>Wen, D.</au><au>Zhao, X. F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transmembrane Protease TMPRSS4 Promotes the Formation and Development of Mismatch Repair Deficient Colon Cancer Liver Metastasis</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>171</volume><issue>2</issue><spage>242</spage><epage>246</epage><pages>242-246</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>We studied metastasis-promoting effect of transmembrane protease TMPRSS4 on mismatch repair (MMR)-deficient colorectal cancer liver metastasis in BALB/c nude mouse model. Histomorphological and histopathological studies showed that the number of liver metastases in the study group were significantly higher than that in the control group (
p
<0.05). The expression of TMPRSS4 mRNA and protein in the study group were obviously higher than in the control group (
p
<0.05). These findings suggest that TMPRSS4 possesses a metastasis-promoting effect and its low expression can effectively block the progression of MMR-deficient colon cancer liver metastasis.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>34173918</pmid><doi>10.1007/s10517-021-05203-6</doi><tpages>5</tpages></addata></record> |
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| ispartof | Bulletin of experimental biology and medicine, 2021-05, Vol.171 (2), p.242-246 |
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| subjects | Analysis Animals Biomedical and Life Sciences Biomedicine Brain Neoplasms - complications Brain Neoplasms - genetics Brain Neoplasms - pathology Cell Biology Cell Movement - genetics Cell Transformation, Neoplastic - genetics Colon cancer Colonic Neoplasms - genetics Colonic Neoplasms - pathology Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - complications Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Development and progression Disease Progression DNA Mismatch Repair - genetics Female Gene expression Gene Expression Regulation, Neoplastic Humans Internal Medicine Laboratory Medicine Liver Liver cancer Liver Neoplasms - genetics Liver Neoplasms - secondary Membrane Proteins - genetics Membrane Proteins - physiology Metastases Metastasis Mice Mice, Inbred BALB C Mice, Nude Mismatch repair mRNA Neoplastic Syndromes, Hereditary - complications Neoplastic Syndromes, Hereditary - genetics Neoplastic Syndromes, Hereditary - pathology Oncology Pathology Proteases Proteinase RNA Serine Endopeptidases - genetics Serine Endopeptidases - physiology Tumor Cells, Cultured |
| title | Transmembrane Protease TMPRSS4 Promotes the Formation and Development of Mismatch Repair Deficient Colon Cancer Liver Metastasis |
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