Transmembrane Protease TMPRSS4 Promotes the Formation and Development of Mismatch Repair Deficient Colon Cancer Liver Metastasis

We studied metastasis-promoting effect of transmembrane protease TMPRSS4 on mismatch repair (MMR)-deficient colorectal cancer liver metastasis in BALB/c nude mouse model. Histomorphological and histopathological studies showed that the number of liver metastases in the study group were significantly...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2021-05, Vol.171 (2), p.242-246
Hauptverfasser:	Yang, Y. S., Wen, D., Zhao, X. F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Biomedical and Life Sciences Biomedicine Brain Neoplasms - complications Brain Neoplasms - genetics Brain Neoplasms - pathology Cell Biology Cell Movement - genetics Cell Transformation, Neoplastic - genetics Colon cancer Colonic Neoplasms - genetics Colonic Neoplasms - pathology Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - complications Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Development and progression Disease Progression DNA Mismatch Repair - genetics Female Gene expression Gene Expression Regulation, Neoplastic Humans Internal Medicine Laboratory Medicine Liver Liver cancer Liver Neoplasms - genetics Liver Neoplasms - secondary Membrane Proteins - genetics Membrane Proteins - physiology Metastases Metastasis Mice Mice, Inbred BALB C Mice, Nude Mismatch repair mRNA Neoplastic Syndromes, Hereditary - complications Neoplastic Syndromes, Hereditary - genetics Neoplastic Syndromes, Hereditary - pathology Oncology Pathology Proteases Proteinase RNA Serine Endopeptidases - genetics Serine Endopeptidases - physiology Tumor Cells, Cultured
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Zusammenfassung:	We studied metastasis-promoting effect of transmembrane protease TMPRSS4 on mismatch repair (MMR)-deficient colorectal cancer liver metastasis in BALB/c nude mouse model. Histomorphological and histopathological studies showed that the number of liver metastases in the study group were significantly higher than that in the control group ( p
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-021-05203-6