Relation of renal function to mid-term prognosis of stable angina patients with high- or low-dose pitavastatin treatment: REAL-CAD substudy

Relation of renal function to mid-term prognosis of stable angina patients with high- or low-dose pitavastatin treatment: REAL-CAD substudy

It has not yet been established whether higher-dose statins have beneficial effects on cardiovascular events in patients with stable coronary artery disease (CAD) and renal dysfunction. The REAL-CAD study is a prospective, multicenter, open-label trial. As a substudy, we categorized patients by an e...

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Veröffentlicht in:The American heart journal 2021-10, Vol.240, p.89-100
Hauptverfasser: Abe, Mitsuru, Ozaki, Yukio, Takahashi, Hiroshi, Ishii, Mitsuru, Masunaga, Nobutoyo, Ismail, Tevfik F., Iimuro, Satoshi, Fujita, Retsu, Iwata, Hiroshi, Sakuma, Ichiro, Nakagawa, Yoshihisa, Hibi, Kiyoshi, Hiro, Takafumi, Fukumoto, Yoshihiro, Hokimoto, Seiji, Miyauchi, Katsumi, Ogawa, Hisao, Daida, Hiroyuki, Shimokawa, Hiroaki, Saito, Yasushi, Matsuzaki, Masunori, Akao, Masaharu, Kimura, Takeshi, Nagai, Ryozo
Format: Artikel
Sprache:eng
Schlagworte:
Angina
Angina pectoris
Cardiovascular disease
Cardiovascular events
Cerebral infarction
Cholesterol
Confidence intervals
Coronary artery
Coronary artery disease
Coronary vessels
Creatinine
Drug dosages
Epidermal growth factor receptors
Glomerular filtration rate
Hazard assessment
Health hazards
Heart diseases
Ischemia
Lipids
Low density lipoprotein
Medical prognosis
Myocardial infarction
Patients
Rank tests
Renal function
Statins
Statistical models
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Zusammenfassung:It has not yet been established whether higher-dose statins have beneficial effects on cardiovascular events in patients with stable coronary artery disease (CAD) and renal dysfunction. The REAL-CAD study is a prospective, multicenter, open-label trial. As a substudy, we categorized patients by an estimated glomerular filtration rate (eGFR) as follows: eGFR ≥60 (n = 7,768); eGFR ≥45 and
ISSN:0002-8703
1097-6744
DOI:10.1016/j.ahj.2021.06.009