Vaginal bacterial load in the second trimester is associated with early preterm birth recurrence: a nested case–control study

Objective To assess the association between vaginal microbiome (VMB) composition and recurrent early spontaneous preterm birth (sPTB)/preterm prelabour rupture of membranes (PPROM). Design Nested case–control study. Setting UK tertiary referral hospital. Sample High‐risk women with previous sPTB/PPR...

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Veröffentlicht in:	BJOG : an international journal of obstetrics and gynaecology 2021-12, Vol.128 (13), p.2061-2072
Hauptverfasser:	Goodfellow, L, Verwijs, MC, Care, A, Sharp, A, Ivandic, J, Poljak, B, Roberts, D, Bronowski, C, Gill, AC, Darby, AC, Alfirevic, A, Muller‐Myhsok, B, Alfirevic, Z, van de Wijgert, JHHM
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Bacteria Bacterial Load Birth Case-Control Studies Dysbacteriosis Female Fetal Membranes, Premature Rupture - epidemiology Fetal Membranes, Premature Rupture - microbiology Gestation Gestational Age Humans Lactobacillus Lactobacillus - genetics Lactobacillus - isolation & purification Lactobacillus crispatus - genetics Lactobacillus crispatus - isolation & purification Microbiomes Microbiota - genetics Pregnancy Pregnancy Trimester, Second Premature birth Premature Birth - epidemiology Premature Birth - microbiology preterm premature rupture of membranes RNA, Ribosomal, 16S - genetics rRNA 16S spontaneous preterm birth Vagina Vagina - microbiology vaginal microbiome Young Adult
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Beschreibung
Zusammenfassung:	Objective To assess the association between vaginal microbiome (VMB) composition and recurrent early spontaneous preterm birth (sPTB)/preterm prelabour rupture of membranes (PPROM). Design Nested case–control study. Setting UK tertiary referral hospital. Sample High‐risk women with previous sPTB/PPROM
ISSN:	1470-0328 1471-0528
DOI:	10.1111/1471-0528.16816