Functional Micro‐/Nanomaterials for Multiplexed Biodetection

When analyzing biological phenomena and processes, multiplexed biodetection has many advantages over single‐factor biodetection and is highly relevant to both human health issues and advancements in the life sciences. However, many key problems with current multiplexed biodetection strategies remain unresolved. Herein, the main issues are analyzed and summarized: 1) generating sufficient signal to label targets, 2) improving the signal‐to‐noise ratio to ensure total detection sensitivity, and 3) simplifying the detection process to reduce the time and labor costs of multiple target detection. Then, available solutions made possible by designing and controlling the properties of micro‐ and nanomaterials are introduced. The aim is to emphasize the role that micro‐/nanomaterials can play in the improvement of multiplexed biodetection strategies. Through analyzing existing problems, introducing state‐of‐the‐art developments regarding relevant materials, and discussing future directions of the field, it is hopeful to help promote necessary developments in multiplexed biodetection and associated scientific research. Multiplexed detection has gradually occupied the main development trend in the field of biodetection due to its rich information, accurate results, and high efficiency. The challenges of multiplexed detection in three aspects of coding library, detection performance, and workflow are analyzed, and the strategies are provided from the perspective of functional micro‐/nanomaterials.