Genetic characterization and phylogenetic variations of human adenovirus‐F strains circulating in eastern India during 2017–2020

Human adenovirus‐F (HAdV‐F) (genotype 40/41) is the second‐most leading cause of pediatric gastroenteritis after rotavirus, worldwide, accounting for 2.8%–11.8% of infantile diarrheal cases. Earlier studies across eastern India revealed a shift in the predominance of genotypes from HAdV41 in 2007–09...

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Veröffentlicht in:Journal of medical virology 2021-11, Vol.93 (11), p.6180-6190
Hauptverfasser: Chandra, Pritam, Lo, Mahadeb, Mitra, Suvrotoa, Banerjee, Anindita, Saha, Priyanka, Okamoto, Keinosuke, Deb, Alok Kumar, Ghosh, Sanat Kumar, Manna, Asis, Dutta, Shanta, Chawla‐Sarkar, Mamta
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Sprache:eng
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Zusammenfassung:Human adenovirus‐F (HAdV‐F) (genotype 40/41) is the second‐most leading cause of pediatric gastroenteritis after rotavirus, worldwide, accounting for 2.8%–11.8% of infantile diarrheal cases. Earlier studies across eastern India revealed a shift in the predominance of genotypes from HAdV41 in 2007–09 to HAdV40 in 2013–14. Thus, the surveillance for HAdV‐F genotypes in this geographical setting was undertaken over 2017–2020 to analyze the viral evolutionary dynamics. A total of 3882 stool samples collected from children (≤5 years) were screened for HAdV‐F positivity by conventional PCR. The hypervariable regions of the hexon and the partial shaft region of long fiber genes were amplified, sequenced, and phylogenetically analyzed with respect to the prototype strains. A marginal decrease in enteric HAdV prevalence was observed (9.04%, n = 351/3882) compared to the previous report (11.8%) in this endemic setting. Children
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.27136