Hemodialysis leads to plasma depletion of lectin complement pathway initiator molecule ficolin‐2

Introduction This study aimed to investigate changes in complement system‐related molecules in patients undergoing hemodialysis. Methods Patients >18 years of age on maintenance hemodialysis were included. Using enzyme‐linked immunosorbent assays (ELISA) methods complement related molecules ficolin‐1, ficolin‐2, ficolin‐3 mannose‐binding lectin, long pentraxin 3, complement activation products C3c, and complement activation potentials were measured before and after a single hemodialysis treatment. All patients were dialyzed with synthetic high flux filters >1.6 m2, respectively, Polyamix and Polysulfone, and the Kt/V was maintained >1.3. Findings Three hundred and four patients were included. There was a modest decrease in plasma level of ficolin‐1 (p