Transition-metal-free nucleophilic 211At-astatination of spirocyclic aryliodonium ylides

Transition-metal-free nucleophilic 211At-astatination of spirocyclic aryliodonium ylides

The transition-metal-free 211At-astatination of spirocyclic aryliodonium ylides via a nucleophilic aromatic substitution reaction is described. This method enables the preparation of 211At-radiolabeled compounds derived from multi-functionalized molecules and heteroarenes in good to excellent radioc...

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Veröffentlicht in:Organic & biomolecular chemistry 2021-09, Vol.19 (25), p.5525-5528
Hauptverfasser: Matsuoka, Keitaro, Obata, Honoka, Nagatsu, Kotaro, Kojima, Masahiro, Yoshino, Tatsuhiko, Ogawa, Mikako, Matsunaga, Shigeki
Format: Artikel
Sprache:eng
Schlagworte:
Radiochemistry
Substitution reactions
Transition metals
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Zusammenfassung:The transition-metal-free 211At-astatination of spirocyclic aryliodonium ylides via a nucleophilic aromatic substitution reaction is described. This method enables the preparation of 211At-radiolabeled compounds derived from multi-functionalized molecules and heteroarenes in good to excellent radiochemical yields.
ISSN:1477-0520
1477-0539
DOI:10.1039/d1ob00789k