Transport-driven engineering of liposomes for delivery of α-particle radiotherapy to solid tumors: effect on inhibition of tumor progression and onset delay of spontaneous metastases

Transport-driven engineering of liposomes for delivery of α-particle radiotherapy to solid tumors: effect on inhibition of tumor progression and onset delay of spontaneous metastases

Purpose Highly cytotoxic α-particle radiotherapy delivered by tumor-selective nanocarriers is evaluated on metastatic Triple Negative Breast Cancer (TNBC). On vascularized tumors, the limited penetration of nanocarriers (

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Veröffentlicht in:European journal of nuclear medicine and molecular imaging 2021-12, Vol.48 (13), p.4246-4258
Hauptverfasser: Prasad, Aprameya, Nair, Rajiv, Bhatavdekar, Omkar, Howe, Alaina, Salerno, Dominick, Sempkowski, Michelle, Josefsson, Anders, Pacheco-Torres, Jesus, Bhujwalla, Zaver M., Gabrielson, Kathleen L., Sgouros, George, Sofou, Stavroula
Format: Artikel
Sprache:eng
Schlagworte:
Actinium
Animal models
Breast cancer
Cardiology
Cytotoxicity
Emitters
Encapsulation
Extracellular matrix
Imaging
Irradiation
Liposomes
Medicine
Medicine & Public Health
Metastases
Metastasis
Nuclear Medicine
Oncology
Original Article
Orthopedics
Radiation therapy
Radioactivity
Radiology
Solid tumors
Translational research
Tumors
Xenografts
Xenotransplantation
α Radiation
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Zusammenfassung:Purpose Highly cytotoxic α-particle radiotherapy delivered by tumor-selective nanocarriers is evaluated on metastatic Triple Negative Breast Cancer (TNBC). On vascularized tumors, the limited penetration of nanocarriers (
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-021-05406-z