Of mitochondrion and COVID-19

COVID-19, a pandemic disease caused by a viral infection, is associated with a high mortality rate. Most of the signs and symptoms, e.g. cytokine storm, electrolytes imbalances, thromboembolism, etc., are related to mitochondrial dysfunction. Therefore, targeting mitochondrion will represent a more...

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Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2021-01, Vol.36 (1), p.1258-1266
Hauptverfasser:	Alfarouk, Khalid Omer, Alhoufie, Sari T. S., Hifny, Abdelhameed, Schwartz, Laurent, Alqahtani, Ali S., Ahmed, Samrein B. M., Alqahtani, Ali M., Alqahtani, Saad S., Muddathir, Abdel Khalig, Ali, Heyam, Bashir, Adil H. H., Ibrahim, Muntaser E., Greco, Maria Raffaella, Cardone, Rosa A., Harguindey, Salvador, Reshkin, Stephan Joel
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - chemistry Antiviral Agents - pharmacology COVID-19 COVID-19 - metabolism COVID-19 - pathology COVID-19 Drug Treatment cytokine storm Humans inflammation Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology mitochondrion Review SARS-CoV-2 - drug effects SARS-CoV-2 - pathogenicity treatment
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Beschreibung
Zusammenfassung:	COVID-19, a pandemic disease caused by a viral infection, is associated with a high mortality rate. Most of the signs and symptoms, e.g. cytokine storm, electrolytes imbalances, thromboembolism, etc., are related to mitochondrial dysfunction. Therefore, targeting mitochondrion will represent a more rational treatment of COVID-19. The current work outlines how COVID-19's signs and symptoms are related to the mitochondrion. Proper understanding of the underlying causes might enhance the opportunity to treat COVID-19.
ISSN:	1475-6366 1475-6374
DOI:	10.1080/14756366.2021.1937144