Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study
Fetal growth restriction arising from placental insufficiency is a leading cause of stillbirth. We recently identified low maternal circulating SPINT1 concentrations as a novel biomarker of poor fetal growth. Here we measured SPINT1 in a prospective cohort in Singapore. Circulating SPINT1 concentrat...
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| Veröffentlicht in: | Placenta (Eastbourne) 2021-07, Vol.110, p.24-28 |
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| creator | Kaitu'u-Lino, Tu'uhevaha J. Tong, Stephen Walker, Susan P. MacDonald, Teresa M. Cannon, Ping Nguyen, Tuong-Vi Sadananthan, Suresh Anand Tint, Mya-Thway Ong, Yi Ying Ling, Loy See Gluckman, Peter D. Chong, Yap-Seng Godfrey, Keith M. Chan, Shiao-Yng Tan, Kok Hian Lee, Yung Seng Michael, Navin Eriksson, Johan G. Wlodek, Mary E. |
| description | Fetal growth restriction arising from placental insufficiency is a leading cause of stillbirth. We recently identified low maternal circulating SPINT1 concentrations as a novel biomarker of poor fetal growth. Here we measured SPINT1 in a prospective cohort in Singapore. Circulating SPINT1 concentrations were significantly lower among 141 pregnant women destined to deliver small-for-gestational age infants (birthweight |
| doi_str_mv | 10.1016/j.placenta.2021.05.007 |
| format | Article |
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•SPINT1 was reduced at 26 weeks' gestation in those destined to deliver a <10th centile infant.•SPINT1 was most reduced in those delivering a <3rd centile baby.•SPINT1 at 26 weeks' was not associated with infant body composition at birth.•This study validates prior findings that low maternal SPINT1 is associated with poor fetal growth.</description><identifier>ISSN: 0143-4004</identifier><identifier>EISSN: 1532-3102</identifier><identifier>DOI: 10.1016/j.placenta.2021.05.007</identifier><identifier>PMID: 34102451</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adult ; Biomarker ; Birth Weight - physiology ; Case-Control Studies ; Cohort Studies ; Down-Regulation ; Female ; Fetal growth restriction ; Fetal Growth Retardation - blood ; Fetal Growth Retardation - epidemiology ; Gestational Age ; Humans ; Infant, Newborn ; Infant, Small for Gestational Age ; Outcome Assessment, Health Care ; Placental Insufficiency - blood ; Placental Insufficiency - epidemiology ; Pregnancy ; Pregnancy Outcome - epidemiology ; Pregnancy Trimester, Second - blood ; Proteinase Inhibitory Proteins, Secretory - analysis ; Proteinase Inhibitory Proteins, Secretory - blood ; SGA ; Singapore - epidemiology ; SPINT1 ; Stillbirth - epidemiology</subject><ispartof>Placenta (Eastbourne), 2021-07, Vol.110, p.24-28</ispartof><rights>2021</rights><rights>Copyright © 2021. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-5873f7e1e4c5b5a4857a89676de417342ccad13faf81bceab4418fcd6fd6d5143</citedby><cites>FETCH-LOGICAL-c368t-5873f7e1e4c5b5a4857a89676de417342ccad13faf81bceab4418fcd6fd6d5143</cites><orcidid>0000-0002-6170-2108 ; 0000-0001-8653-7893 ; 0000-0003-3072-765X ; 0000-0002-9205-5580 ; 0000-0001-5938-1694 ; 0000-0001-9099-7745 ; 0000-0002-4643-0618 ; 0000-0003-1945-0266</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.placenta.2021.05.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34102451$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaitu'u-Lino, Tu'uhevaha J.</creatorcontrib><creatorcontrib>Tong, Stephen</creatorcontrib><creatorcontrib>Walker, Susan P.</creatorcontrib><creatorcontrib>MacDonald, Teresa M.</creatorcontrib><creatorcontrib>Cannon, Ping</creatorcontrib><creatorcontrib>Nguyen, Tuong-Vi</creatorcontrib><creatorcontrib>Sadananthan, Suresh Anand</creatorcontrib><creatorcontrib>Tint, Mya-Thway</creatorcontrib><creatorcontrib>Ong, Yi Ying</creatorcontrib><creatorcontrib>Ling, Loy See</creatorcontrib><creatorcontrib>Gluckman, Peter D.</creatorcontrib><creatorcontrib>Chong, Yap-Seng</creatorcontrib><creatorcontrib>Godfrey, Keith M.</creatorcontrib><creatorcontrib>Chan, Shiao-Yng</creatorcontrib><creatorcontrib>Tan, Kok Hian</creatorcontrib><creatorcontrib>Lee, Yung Seng</creatorcontrib><creatorcontrib>Michael, Navin</creatorcontrib><creatorcontrib>Eriksson, Johan G.</creatorcontrib><creatorcontrib>Wlodek, Mary E.</creatorcontrib><title>Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study</title><title>Placenta (Eastbourne)</title><addtitle>Placenta</addtitle><description>Fetal growth restriction arising from placental insufficiency is a leading cause of stillbirth. We recently identified low maternal circulating SPINT1 concentrations as a novel biomarker of poor fetal growth. Here we measured SPINT1 in a prospective cohort in Singapore. Circulating SPINT1 concentrations were significantly lower among 141 pregnant women destined to deliver small-for-gestational age infants (birthweight <10th centile), compared to 772 controls (p < 0.01) at as early as 26 weeks’ gestation. There were no correlations between infant body composition and circulating SPINT1 concentrations at 26 weeks. This provides validation that low maternal SPINT1 concentration is associated with poor fetal growth.
•SPINT1 was reduced at 26 weeks' gestation in those destined to deliver a <10th centile infant.•SPINT1 was most reduced in those delivering a <3rd centile baby.•SPINT1 at 26 weeks' was not associated with infant body composition at birth.•This study validates prior findings that low maternal SPINT1 is associated with poor fetal growth.</description><subject>Adult</subject><subject>Biomarker</subject><subject>Birth Weight - physiology</subject><subject>Case-Control Studies</subject><subject>Cohort Studies</subject><subject>Down-Regulation</subject><subject>Female</subject><subject>Fetal growth restriction</subject><subject>Fetal Growth Retardation - blood</subject><subject>Fetal Growth Retardation - epidemiology</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Small for Gestational Age</subject><subject>Outcome Assessment, Health Care</subject><subject>Placental Insufficiency - blood</subject><subject>Placental Insufficiency - epidemiology</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome - epidemiology</subject><subject>Pregnancy Trimester, Second - blood</subject><subject>Proteinase Inhibitory Proteins, Secretory - analysis</subject><subject>Proteinase Inhibitory Proteins, Secretory - blood</subject><subject>SGA</subject><subject>Singapore - epidemiology</subject><subject>SPINT1</subject><subject>Stillbirth - epidemiology</subject><issn>0143-4004</issn><issn>1532-3102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhi0EokvhFSofyyGp7dhJlhOoKkulQpF2e7Zm7cluliQOtsOqj8Ob4mjbXjnZh-__RzMfIRec5Zzx8uqQjx0YHCLkggmeM5UzVr0iC64KkRWciddkwbgsMsmYPCPvQjgwxpaSi7fkrJAJkIovyN_vENEP0FHTejN1ENthR9c_b39sOG0D9Wgng5a2Aw09dF3WOJ_tMMQEujkGO6Sjx90Ag2kxUIhUlPSI-Ct8oivvjnPfNM4F6_SF0Xmk0R3B20D3CF3cUzdF4_oUvlw9rDf3H6lxe-cjDXGyj-_Jmwa6gB-e3nPy8PVmc_0tu7tf3V5_uctMUdYxU3VVNBVylEZtFchaVVAvy6q0KHlVSGEMWF400NR8axC2UvK6MbZsbGlVOtQ5uTz1jt79ntKGum-Dwa6DAd0UtFDFUglRViqh5Qk13oXgsdGjb3vwj5ozPevRB_2sR896NFM66UnBi6cZ07ZH-xJ79pGAzycA06Z_WvQ6pKsOyUDr0URtXfu_Gf8A9c6mfw</recordid><startdate>202107</startdate><enddate>202107</enddate><creator>Kaitu'u-Lino, Tu'uhevaha J.</creator><creator>Tong, Stephen</creator><creator>Walker, Susan P.</creator><creator>MacDonald, Teresa M.</creator><creator>Cannon, Ping</creator><creator>Nguyen, Tuong-Vi</creator><creator>Sadananthan, Suresh Anand</creator><creator>Tint, Mya-Thway</creator><creator>Ong, Yi Ying</creator><creator>Ling, Loy See</creator><creator>Gluckman, Peter D.</creator><creator>Chong, Yap-Seng</creator><creator>Godfrey, Keith M.</creator><creator>Chan, Shiao-Yng</creator><creator>Tan, Kok Hian</creator><creator>Lee, Yung Seng</creator><creator>Michael, Navin</creator><creator>Eriksson, Johan G.</creator><creator>Wlodek, Mary E.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6170-2108</orcidid><orcidid>https://orcid.org/0000-0001-8653-7893</orcidid><orcidid>https://orcid.org/0000-0003-3072-765X</orcidid><orcidid>https://orcid.org/0000-0002-9205-5580</orcidid><orcidid>https://orcid.org/0000-0001-5938-1694</orcidid><orcidid>https://orcid.org/0000-0001-9099-7745</orcidid><orcidid>https://orcid.org/0000-0002-4643-0618</orcidid><orcidid>https://orcid.org/0000-0003-1945-0266</orcidid></search><sort><creationdate>202107</creationdate><title>Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study</title><author>Kaitu'u-Lino, Tu'uhevaha J. ; Tong, Stephen ; Walker, Susan P. ; MacDonald, Teresa M. ; Cannon, Ping ; Nguyen, Tuong-Vi ; Sadananthan, Suresh Anand ; Tint, Mya-Thway ; Ong, Yi Ying ; Ling, Loy See ; Gluckman, Peter D. ; Chong, Yap-Seng ; Godfrey, Keith M. ; Chan, Shiao-Yng ; Tan, Kok Hian ; Lee, Yung Seng ; Michael, Navin ; Eriksson, Johan G. ; Wlodek, Mary E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-5873f7e1e4c5b5a4857a89676de417342ccad13faf81bceab4418fcd6fd6d5143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Biomarker</topic><topic>Birth Weight - physiology</topic><topic>Case-Control Studies</topic><topic>Cohort Studies</topic><topic>Down-Regulation</topic><topic>Female</topic><topic>Fetal growth restriction</topic><topic>Fetal Growth Retardation - blood</topic><topic>Fetal Growth Retardation - epidemiology</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Small for Gestational Age</topic><topic>Outcome Assessment, Health Care</topic><topic>Placental Insufficiency - blood</topic><topic>Placental Insufficiency - epidemiology</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome - epidemiology</topic><topic>Pregnancy Trimester, Second - blood</topic><topic>Proteinase Inhibitory Proteins, Secretory - analysis</topic><topic>Proteinase Inhibitory Proteins, Secretory - blood</topic><topic>SGA</topic><topic>Singapore - epidemiology</topic><topic>SPINT1</topic><topic>Stillbirth - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaitu'u-Lino, Tu'uhevaha J.</creatorcontrib><creatorcontrib>Tong, Stephen</creatorcontrib><creatorcontrib>Walker, Susan P.</creatorcontrib><creatorcontrib>MacDonald, Teresa M.</creatorcontrib><creatorcontrib>Cannon, Ping</creatorcontrib><creatorcontrib>Nguyen, Tuong-Vi</creatorcontrib><creatorcontrib>Sadananthan, Suresh Anand</creatorcontrib><creatorcontrib>Tint, Mya-Thway</creatorcontrib><creatorcontrib>Ong, Yi Ying</creatorcontrib><creatorcontrib>Ling, Loy See</creatorcontrib><creatorcontrib>Gluckman, Peter D.</creatorcontrib><creatorcontrib>Chong, Yap-Seng</creatorcontrib><creatorcontrib>Godfrey, Keith M.</creatorcontrib><creatorcontrib>Chan, Shiao-Yng</creatorcontrib><creatorcontrib>Tan, Kok Hian</creatorcontrib><creatorcontrib>Lee, Yung Seng</creatorcontrib><creatorcontrib>Michael, Navin</creatorcontrib><creatorcontrib>Eriksson, Johan G.</creatorcontrib><creatorcontrib>Wlodek, Mary E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Placenta (Eastbourne)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaitu'u-Lino, Tu'uhevaha J.</au><au>Tong, Stephen</au><au>Walker, Susan P.</au><au>MacDonald, Teresa M.</au><au>Cannon, Ping</au><au>Nguyen, Tuong-Vi</au><au>Sadananthan, Suresh Anand</au><au>Tint, Mya-Thway</au><au>Ong, Yi Ying</au><au>Ling, Loy See</au><au>Gluckman, Peter D.</au><au>Chong, Yap-Seng</au><au>Godfrey, Keith M.</au><au>Chan, Shiao-Yng</au><au>Tan, Kok Hian</au><au>Lee, Yung Seng</au><au>Michael, Navin</au><au>Eriksson, Johan G.</au><au>Wlodek, Mary E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study</atitle><jtitle>Placenta (Eastbourne)</jtitle><addtitle>Placenta</addtitle><date>2021-07</date><risdate>2021</risdate><volume>110</volume><spage>24</spage><epage>28</epage><pages>24-28</pages><issn>0143-4004</issn><eissn>1532-3102</eissn><abstract>Fetal growth restriction arising from placental insufficiency is a leading cause of stillbirth. We recently identified low maternal circulating SPINT1 concentrations as a novel biomarker of poor fetal growth. Here we measured SPINT1 in a prospective cohort in Singapore. Circulating SPINT1 concentrations were significantly lower among 141 pregnant women destined to deliver small-for-gestational age infants (birthweight <10th centile), compared to 772 controls (p < 0.01) at as early as 26 weeks’ gestation. There were no correlations between infant body composition and circulating SPINT1 concentrations at 26 weeks. This provides validation that low maternal SPINT1 concentration is associated with poor fetal growth.
•SPINT1 was reduced at 26 weeks' gestation in those destined to deliver a <10th centile infant.•SPINT1 was most reduced in those delivering a <3rd centile baby.•SPINT1 at 26 weeks' was not associated with infant body composition at birth.•This study validates prior findings that low maternal SPINT1 is associated with poor fetal growth.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>34102451</pmid><doi>10.1016/j.placenta.2021.05.007</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-6170-2108</orcidid><orcidid>https://orcid.org/0000-0001-8653-7893</orcidid><orcidid>https://orcid.org/0000-0003-3072-765X</orcidid><orcidid>https://orcid.org/0000-0002-9205-5580</orcidid><orcidid>https://orcid.org/0000-0001-5938-1694</orcidid><orcidid>https://orcid.org/0000-0001-9099-7745</orcidid><orcidid>https://orcid.org/0000-0002-4643-0618</orcidid><orcidid>https://orcid.org/0000-0003-1945-0266</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0143-4004 |
| ispartof | Placenta (Eastbourne), 2021-07, Vol.110, p.24-28 |
| issn | 0143-4004 1532-3102 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Biomarker Birth Weight - physiology Case-Control Studies Cohort Studies Down-Regulation Female Fetal growth restriction Fetal Growth Retardation - blood Fetal Growth Retardation - epidemiology Gestational Age Humans Infant, Newborn Infant, Small for Gestational Age Outcome Assessment, Health Care Placental Insufficiency - blood Placental Insufficiency - epidemiology Pregnancy Pregnancy Outcome - epidemiology Pregnancy Trimester, Second - blood Proteinase Inhibitory Proteins, Secretory - analysis Proteinase Inhibitory Proteins, Secretory - blood SGA Singapore - epidemiology SPINT1 Stillbirth - epidemiology |
| title | Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study |
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