Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study

Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study

Fetal growth restriction arising from placental insufficiency is a leading cause of stillbirth. We recently identified low maternal circulating SPINT1 concentrations as a novel biomarker of poor fetal growth. Here we measured SPINT1 in a prospective cohort in Singapore. Circulating SPINT1 concentrat...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Placenta (Eastbourne) 2021-07, Vol.110, p.24-28
Hauptverfasser: Kaitu'u-Lino, Tu'uhevaha J., Tong, Stephen, Walker, Susan P., MacDonald, Teresa M., Cannon, Ping, Nguyen, Tuong-Vi, Sadananthan, Suresh Anand, Tint, Mya-Thway, Ong, Yi Ying, Ling, Loy See, Gluckman, Peter D., Chong, Yap-Seng, Godfrey, Keith M., Chan, Shiao-Yng, Tan, Kok Hian, Lee, Yung Seng, Michael, Navin, Eriksson, Johan G., Wlodek, Mary E.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Biomarker
Birth Weight - physiology
Case-Control Studies
Cohort Studies
Down-Regulation
Female
Fetal growth restriction
Fetal Growth Retardation - blood
Fetal Growth Retardation - epidemiology
Gestational Age
Humans
Infant, Newborn
Infant, Small for Gestational Age
Outcome Assessment, Health Care
Placental Insufficiency - blood
Placental Insufficiency - epidemiology
Pregnancy
Pregnancy Outcome - epidemiology
Pregnancy Trimester, Second - blood
Proteinase Inhibitory Proteins, Secretory - analysis
Proteinase Inhibitory Proteins, Secretory - blood
SGA
Singapore - epidemiology
SPINT1
Stillbirth - epidemiology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Fetal growth restriction arising from placental insufficiency is a leading cause of stillbirth. We recently identified low maternal circulating SPINT1 concentrations as a novel biomarker of poor fetal growth. Here we measured SPINT1 in a prospective cohort in Singapore. Circulating SPINT1 concentrations were significantly lower among 141 pregnant women destined to deliver small-for-gestational age infants (birthweight
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2021.05.007