The prevalence and functional characteristics of CrpP-like in Pseudomonas aeruginosa isolates from China

Modifying enzyme-CrpP and its variants reduced the MICs of fluoroquinolones in Pseudomonas aeruginosa . This study investigated the dissemination and functional characteristics of CrpP-like in P. aeruginosa from China. The positive rate of crpP -like genes in 228 P. aeruginosa was 25.4% (58/228), an...

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Veröffentlicht in:	European journal of clinical microbiology & infectious diseases 2021-12, Vol.40 (12), p.2651-2656
Hauptverfasser:	Xu, Ye, Zhang, Ying, Zheng, Xiangkuo, Yu, Kaihang, Sun, Yao, Liao, Wenli, Jia, Huaiyu, Xu, Chunquan, Zhou, Tieli, Shen, Mo
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibiotics Antimicrobial agents Bacterial Proteins - genetics Bacterial Proteins - metabolism Biomedical and Life Sciences Biomedicine Brief Report China Ciprofloxacin - pharmacology Enzymes Experiments Fluoroquinolones Genes Genetic diversity Genetic transformation Hospitals Humans Infectious diseases Internal Medicine Laboratories Medical Microbiology Microbial Sensitivity Tests Mutation Plasmids Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - enzymology Pseudomonas aeruginosa - genetics Pseudomonas aeruginosa - isolation & purification Pseudomonas Infections - microbiology
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Zusammenfassung:	Modifying enzyme-CrpP and its variants reduced the MICs of fluoroquinolones in Pseudomonas aeruginosa . This study investigated the dissemination and functional characteristics of CrpP-like in P. aeruginosa from China. The positive rate of crpP -like genes in 228 P. aeruginosa was 25.4% (58/228), and 6 new crpP -like genes were determined. Transformation experiments showed that CrpP-like had a low effect on CIP and LEV susceptibility. The genetic of crpP -positive was diverse. Furthermore, the mean expression level of crpP was no statistical difference between fluoroquinolone-susceptible and -resistant group ( P > 0.05). CrpP-like may not play a significant role in fluoroquinolone resistance in P. aeruginosa .
ISSN:	0934-9723 1435-4373
DOI:	10.1007/s10096-021-04287-2