Selected ion flow tube mass spectrometry for targeted analysis of volatile organic compounds in human breath

Selected ion flow tube mass spectrometry for targeted analysis of volatile organic compounds in human breath

The analysis of volatile organic compounds (VOCs) within breath for noninvasive disease detection and monitoring is an emergent research field that has the potential to reshape current clinical practice. However, adoption of breath testing has been limited by a lack of standardization. This protocol...

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Veröffentlicht in:Nature protocols 2021-07, Vol.16 (7), p.3419-3438
Hauptverfasser: Belluomo, Ilaria, Boshier, Piers R., Myridakis, Antonis, Vadhwana, Bhamini, Markar, Sheraz R., Spanel, Patrik, Hanna, George B.
Format: Artikel
Sprache:eng
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Adolescent
Adult
Aged
Aged, 80 and over
Alcohols
Aldehydes
Alkanes
Analytical Chemistry
Biological Techniques
Biomedical and Life Sciences
Breath tests
Breath Tests - methods
Chemical properties
Computational Biology/Bioinformatics
Diagnosis, Noninvasive
Disease detection
Fatty acids
Health aspects
Humans
Ions
Life Sciences
Mass spectrometry
Mass Spectrometry - methods
Mass spectroscopy
Methods
Microarrays
Middle Aged
Monitoring
Organic Chemistry
Organic compounds
Phenols
Protocol
Scientific imaging
Spectroscopy
Standardization
VOCs
Volatile organic compounds
Volatile Organic Compounds - analysis
Workflow
Young Adult
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Beschreibung
Zusammenfassung:The analysis of volatile organic compounds (VOCs) within breath for noninvasive disease detection and monitoring is an emergent research field that has the potential to reshape current clinical practice. However, adoption of breath testing has been limited by a lack of standardization. This protocol provides a comprehensive workflow for online and offline breath analysis using selected ion flow tube mass spectrometry (SIFT-MS). Following the suggested protocol, 50 human breath samples can be analyzed and interpreted in
ISSN:1754-2189
1750-2799
DOI:10.1038/s41596-021-00542-0