Circulating vitamin C and the risk of cardiovascular diseases: A Mendelian randomization study

Circulating vitamin C and the risk of cardiovascular diseases: A Mendelian randomization study

The impact of vitamin C supplementation on the risk of cardiovascular diseases (CVDs) remains uncertain with inconsistent evidence obtained from observational studies and randomized clinical trials (RCTs). We aimed to assess possible causal associations of vitamin C with major CVD events as well as...

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Veröffentlicht in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2021-07, Vol.31 (8), p.2398-2406
Hauptverfasser: Zhu, Jiahao, Ling, Yuxiao, Tse, Lap A., Kinra, Sanjay, Li, Yingjun
Format: Artikel
Sprache:eng
Schlagworte:
Cardiovascular diseases
Mendelian randomization
Risk factors
Vitamin C
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Zusammenfassung:The impact of vitamin C supplementation on the risk of cardiovascular diseases (CVDs) remains uncertain with inconsistent evidence obtained from observational studies and randomized clinical trials (RCTs). We aimed to assess possible causal associations of vitamin C with major CVD events as well as their risk factors using Mendelian randomization (MR) design. Nine genetic variants associated with vitamin C at genome-wide significance (p 
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2021.04.023