Feasibility and efficiency of European guidelines for NAFLD assessment in patients with type 2 diabetes: A prospective study

Feasibility and efficiency of European guidelines for NAFLD assessment in patients with type 2 diabetes: A prospective study

•NAFLD guidelines showed several limitations when applied to type 2 diabetes patients.•Referral rates were high, up to 67% to the hepatologist and 17.5% to liver biopsy.•Positive predictive values of referrals for NASH with significant fibrosis were low.•Further studies are necessary to refine non-i...

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Veröffentlicht in:Diabetes research and clinical practice 2021-07, Vol.177, p.108882-108882, Article 108882
Hauptverfasser: Besutti, Giulia, Bonilauri, Lisa, Manicardi, Elisa, Venturelli, Francesco, Bonelli, Efrem, Monelli, Filippo, Manicardi, Valeria, Valenti, Luca, Ligabue, Guido, Schianchi, Susanna, Massari, Marco, Riva, Nicoletta, Froio, Elisabetta, Tagliavini, Elena, Pattacini, Pierpaolo, Giorgi Rossi, Paolo
Format: Artikel
Sprache:eng
Schlagworte:
Hepatocellular carcinoma
Liver biopsy
Liver fibrosis
Non-alcoholic fatty liver disease
Non-alcoholic steatohepatitis
Type 2 diabetes mellitus
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Zusammenfassung:•NAFLD guidelines showed several limitations when applied to type 2 diabetes patients.•Referral rates were high, up to 67% to the hepatologist and 17.5% to liver biopsy.•Positive predictive values of referrals for NASH with significant fibrosis were low.•Further studies are necessary to refine non-invasive algorithms. We aimed to evaluate the feasibility and efficiency of a guidelines-compliant NAFLD assessment algorithm in patients with newly diagnosed type 2 diabetes (T2D). Consecutive patients aged 
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2021.108882