High‐resolution impedance manometry characterizes the functional role of distal colonic motility in gas transit
Background The colonic motor patterns associated with gas transit are poorly understood. This study describes the application of high‐resolution impedance manometry (HRiM) in the human colon in vivo to characterize distal colonic motility and gas transit; (a) after a meal and (b) after intraluminal...
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| Veröffentlicht in: | Neurogastroenterology and motility 2022-01, Vol.34 (1), p.e14178-n/a |
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| creator | Heitmann, Paul T. Mohd Rosli, Reizal Maslen, Lyn Wiklendt, Lukasz Kumar, Raghu Omari, Taher I. Wattchow, David Costa, Marcello Brookes, Simon J. Dinning, Phil G. |
| description | Background
The colonic motor patterns associated with gas transit are poorly understood. This study describes the application of high‐resolution impedance manometry (HRiM) in the human colon in vivo to characterize distal colonic motility and gas transit; (a) after a meal and (b) after intraluminal gas insufflation into the sigmoid colon.
Methods
HRiM recordings were performed in 19 healthy volunteers, with sensors positioned from the distal descending colon to the proximal rectum. Protocol 1 (n = 10) compared pressure and impedance prior to and after a meal. Protocol 2 (n = 9) compared pressure and impedance before and after gas insufflation into the sigmoid colon (60 mL total volume).
Key Results
Both the meal and gas insufflation resulted in an increase in the prevalence of the 2‐8/minute “cyclic motor pattern” (meal: (t(9) = −6.42, P |
| doi_str_mv | 10.1111/nmo.14178 |
| format | Article |
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The colonic motor patterns associated with gas transit are poorly understood. This study describes the application of high‐resolution impedance manometry (HRiM) in the human colon in vivo to characterize distal colonic motility and gas transit; (a) after a meal and (b) after intraluminal gas insufflation into the sigmoid colon.
Methods
HRiM recordings were performed in 19 healthy volunteers, with sensors positioned from the distal descending colon to the proximal rectum. Protocol 1 (n = 10) compared pressure and impedance prior to and after a meal. Protocol 2 (n = 9) compared pressure and impedance before and after gas insufflation into the sigmoid colon (60 mL total volume).
Key Results
Both the meal and gas insufflation resulted in an increase in the prevalence of the 2‐8/minute “cyclic motor pattern” (meal: (t(9) = −6.42, P<0.001); gas insufflation (t(8) = −3.13, P = 0.01)), and an increase in the number of antegrade and retrograde propagating impedance events (meal: Z = −2.80, P = 0.005; gas insufflation Z = −2.67, P = 0.008). Propagating impedance events temporally preceded antegrade and retrograde propagating contractions, representing a column of luminal gas being displaced ahead of a propagating contraction. Three participants reported an urge to pass flatus and/or flatus during the studies.
Conclusions and Inferences
Initiation of the 2‐8/minute cyclic motor pattern in the distal colon occurs both following a meal and/or as a localized sensorimotor response to gas. The near‐absence of a flatal urge and the temporal association between propagating contractions and gas transit supports the hypothesis that the 2‐8/minute cyclic motor pattern acts as a physiological “brake” modulating rectal filling.
Utilising impedance manometry we quantified the relationships between gas movement and colonic motor patterns. Gas insufflation induced the cyclic motor pattern and our data suggests that this motor pattern acts as a physiological “brake” modulating rectal filling.</description><identifier>ISSN: 1350-1925</identifier><identifier>EISSN: 1365-2982</identifier><identifier>DOI: 10.1111/nmo.14178</identifier><identifier>PMID: 34076936</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; Colon ; Colon - physiology ; Electric Impedance ; Female ; gas ; Gastrointestinal Motility - physiology ; Gastrointestinal Transit - physiology ; Humans ; impedance manometry ; Male ; Manometry - methods ; Middle Aged ; Motility ; propagating contractions ; Sensorimotor system ; Young Adult</subject><ispartof>Neurogastroenterology and motility, 2022-01, Vol.34 (1), p.e14178-n/a</ispartof><rights>2021 John Wiley & Sons Ltd</rights><rights>2021 John Wiley & Sons Ltd.</rights><rights>Copyright © 2022 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3538-545ece7dde48372e7ced2a7ae6002f009005cf34216e65514f96c4d8aaf044653</citedby><cites>FETCH-LOGICAL-c3538-545ece7dde48372e7ced2a7ae6002f009005cf34216e65514f96c4d8aaf044653</cites><orcidid>0000-0001-5635-0876 ; 0000-0002-2991-2762 ; 0000-0001-8727-7747 ; 0000-0001-8910-2801</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fnmo.14178$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fnmo.14178$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,1428,27905,27906,45555,45556,46390,46814</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34076936$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heitmann, Paul T.</creatorcontrib><creatorcontrib>Mohd Rosli, Reizal</creatorcontrib><creatorcontrib>Maslen, Lyn</creatorcontrib><creatorcontrib>Wiklendt, Lukasz</creatorcontrib><creatorcontrib>Kumar, Raghu</creatorcontrib><creatorcontrib>Omari, Taher I.</creatorcontrib><creatorcontrib>Wattchow, David</creatorcontrib><creatorcontrib>Costa, Marcello</creatorcontrib><creatorcontrib>Brookes, Simon J.</creatorcontrib><creatorcontrib>Dinning, Phil G.</creatorcontrib><title>High‐resolution impedance manometry characterizes the functional role of distal colonic motility in gas transit</title><title>Neurogastroenterology and motility</title><addtitle>Neurogastroenterol Motil</addtitle><description>Background
The colonic motor patterns associated with gas transit are poorly understood. This study describes the application of high‐resolution impedance manometry (HRiM) in the human colon in vivo to characterize distal colonic motility and gas transit; (a) after a meal and (b) after intraluminal gas insufflation into the sigmoid colon.
Methods
HRiM recordings were performed in 19 healthy volunteers, with sensors positioned from the distal descending colon to the proximal rectum. Protocol 1 (n = 10) compared pressure and impedance prior to and after a meal. Protocol 2 (n = 9) compared pressure and impedance before and after gas insufflation into the sigmoid colon (60 mL total volume).
Key Results
Both the meal and gas insufflation resulted in an increase in the prevalence of the 2‐8/minute “cyclic motor pattern” (meal: (t(9) = −6.42, P<0.001); gas insufflation (t(8) = −3.13, P = 0.01)), and an increase in the number of antegrade and retrograde propagating impedance events (meal: Z = −2.80, P = 0.005; gas insufflation Z = −2.67, P = 0.008). Propagating impedance events temporally preceded antegrade and retrograde propagating contractions, representing a column of luminal gas being displaced ahead of a propagating contraction. Three participants reported an urge to pass flatus and/or flatus during the studies.
Conclusions and Inferences
Initiation of the 2‐8/minute cyclic motor pattern in the distal colon occurs both following a meal and/or as a localized sensorimotor response to gas. The near‐absence of a flatal urge and the temporal association between propagating contractions and gas transit supports the hypothesis that the 2‐8/minute cyclic motor pattern acts as a physiological “brake” modulating rectal filling.
Utilising impedance manometry we quantified the relationships between gas movement and colonic motor patterns. Gas insufflation induced the cyclic motor pattern and our data suggests that this motor pattern acts as a physiological “brake” modulating rectal filling.</description><subject>Adult</subject><subject>Aged</subject><subject>Colon</subject><subject>Colon - physiology</subject><subject>Electric Impedance</subject><subject>Female</subject><subject>gas</subject><subject>Gastrointestinal Motility - physiology</subject><subject>Gastrointestinal Transit - physiology</subject><subject>Humans</subject><subject>impedance manometry</subject><subject>Male</subject><subject>Manometry - methods</subject><subject>Middle Aged</subject><subject>Motility</subject><subject>propagating contractions</subject><subject>Sensorimotor system</subject><subject>Young Adult</subject><issn>1350-1925</issn><issn>1365-2982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10U9LHDEYBvAglq5ue_ALSMCLHmbN_5k5ilQtbOtFz0OaeceNZJI1ySDbkx_Bz-gnabZreyg0lyTwywN5H4SOKFnQss79GBZU0LrZQweUK1mxtmH727MkFW2ZnKHDlB4JIYoJ9RHNuCC1ark6QE839mH19vIaIQU3ZRs8tuMaeu0N4FH7MEKOG2xWOmqTIdqfkHBeAR4mb7ZcOxyDAxwG3NuUy9UEF7w1eAzZOps32Hr8oMurqH2y-RP6MGiX4PP7Pkf3V1_uLm-q5e3118uLZWW45E0lhQQDdd-DaHjNoDbQM11rUISwgZCWEGkGLhhVoKSkYmiVEX2j9UCEUJLP0ekudx3D0wQpd6NNBpzTHsKUOia5Eg2TbV3oyT_0MUyxfK0oRRtWZqtIUWc7ZWJIKcLQraMdddx0lHTbHrrSQ_e7h2KP3xOnHyP0f-WfwRdwvgPP1sHm_0nd92-3u8hfH7GUAg</recordid><startdate>202201</startdate><enddate>202201</enddate><creator>Heitmann, Paul T.</creator><creator>Mohd Rosli, Reizal</creator><creator>Maslen, Lyn</creator><creator>Wiklendt, Lukasz</creator><creator>Kumar, Raghu</creator><creator>Omari, Taher I.</creator><creator>Wattchow, David</creator><creator>Costa, Marcello</creator><creator>Brookes, Simon J.</creator><creator>Dinning, Phil G.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5635-0876</orcidid><orcidid>https://orcid.org/0000-0002-2991-2762</orcidid><orcidid>https://orcid.org/0000-0001-8727-7747</orcidid><orcidid>https://orcid.org/0000-0001-8910-2801</orcidid></search><sort><creationdate>202201</creationdate><title>High‐resolution impedance manometry characterizes the functional role of distal colonic motility in gas transit</title><author>Heitmann, Paul T. ; Mohd Rosli, Reizal ; Maslen, Lyn ; Wiklendt, Lukasz ; Kumar, Raghu ; Omari, Taher I. ; Wattchow, David ; Costa, Marcello ; Brookes, Simon J. ; Dinning, Phil G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3538-545ece7dde48372e7ced2a7ae6002f009005cf34216e65514f96c4d8aaf044653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Colon</topic><topic>Colon - physiology</topic><topic>Electric Impedance</topic><topic>Female</topic><topic>gas</topic><topic>Gastrointestinal Motility - physiology</topic><topic>Gastrointestinal Transit - physiology</topic><topic>Humans</topic><topic>impedance manometry</topic><topic>Male</topic><topic>Manometry - methods</topic><topic>Middle Aged</topic><topic>Motility</topic><topic>propagating contractions</topic><topic>Sensorimotor system</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heitmann, Paul T.</creatorcontrib><creatorcontrib>Mohd Rosli, Reizal</creatorcontrib><creatorcontrib>Maslen, Lyn</creatorcontrib><creatorcontrib>Wiklendt, Lukasz</creatorcontrib><creatorcontrib>Kumar, Raghu</creatorcontrib><creatorcontrib>Omari, Taher I.</creatorcontrib><creatorcontrib>Wattchow, David</creatorcontrib><creatorcontrib>Costa, Marcello</creatorcontrib><creatorcontrib>Brookes, Simon J.</creatorcontrib><creatorcontrib>Dinning, Phil G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Neurogastroenterology and motility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heitmann, Paul T.</au><au>Mohd Rosli, Reizal</au><au>Maslen, Lyn</au><au>Wiklendt, Lukasz</au><au>Kumar, Raghu</au><au>Omari, Taher I.</au><au>Wattchow, David</au><au>Costa, Marcello</au><au>Brookes, Simon J.</au><au>Dinning, Phil G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High‐resolution impedance manometry characterizes the functional role of distal colonic motility in gas transit</atitle><jtitle>Neurogastroenterology and motility</jtitle><addtitle>Neurogastroenterol Motil</addtitle><date>2022-01</date><risdate>2022</risdate><volume>34</volume><issue>1</issue><spage>e14178</spage><epage>n/a</epage><pages>e14178-n/a</pages><issn>1350-1925</issn><eissn>1365-2982</eissn><abstract>Background
The colonic motor patterns associated with gas transit are poorly understood. This study describes the application of high‐resolution impedance manometry (HRiM) in the human colon in vivo to characterize distal colonic motility and gas transit; (a) after a meal and (b) after intraluminal gas insufflation into the sigmoid colon.
Methods
HRiM recordings were performed in 19 healthy volunteers, with sensors positioned from the distal descending colon to the proximal rectum. Protocol 1 (n = 10) compared pressure and impedance prior to and after a meal. Protocol 2 (n = 9) compared pressure and impedance before and after gas insufflation into the sigmoid colon (60 mL total volume).
Key Results
Both the meal and gas insufflation resulted in an increase in the prevalence of the 2‐8/minute “cyclic motor pattern” (meal: (t(9) = −6.42, P<0.001); gas insufflation (t(8) = −3.13, P = 0.01)), and an increase in the number of antegrade and retrograde propagating impedance events (meal: Z = −2.80, P = 0.005; gas insufflation Z = −2.67, P = 0.008). Propagating impedance events temporally preceded antegrade and retrograde propagating contractions, representing a column of luminal gas being displaced ahead of a propagating contraction. Three participants reported an urge to pass flatus and/or flatus during the studies.
Conclusions and Inferences
Initiation of the 2‐8/minute cyclic motor pattern in the distal colon occurs both following a meal and/or as a localized sensorimotor response to gas. The near‐absence of a flatal urge and the temporal association between propagating contractions and gas transit supports the hypothesis that the 2‐8/minute cyclic motor pattern acts as a physiological “brake” modulating rectal filling.
Utilising impedance manometry we quantified the relationships between gas movement and colonic motor patterns. Gas insufflation induced the cyclic motor pattern and our data suggests that this motor pattern acts as a physiological “brake” modulating rectal filling.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34076936</pmid><doi>10.1111/nmo.14178</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-5635-0876</orcidid><orcidid>https://orcid.org/0000-0002-2991-2762</orcidid><orcidid>https://orcid.org/0000-0001-8727-7747</orcidid><orcidid>https://orcid.org/0000-0001-8910-2801</orcidid></addata></record> |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Free Content |
| subjects | Adult Aged Colon Colon - physiology Electric Impedance Female gas Gastrointestinal Motility - physiology Gastrointestinal Transit - physiology Humans impedance manometry Male Manometry - methods Middle Aged Motility propagating contractions Sensorimotor system Young Adult |
| title | High‐resolution impedance manometry characterizes the functional role of distal colonic motility in gas transit |
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