High‐resolution impedance manometry characterizes the functional role of distal colonic motility in gas transit

Background The colonic motor patterns associated with gas transit are poorly understood. This study describes the application of high‐resolution impedance manometry (HRiM) in the human colon in vivo to characterize distal colonic motility and gas transit; (a) after a meal and (b) after intraluminal...

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Veröffentlicht in:Neurogastroenterology and motility 2022-01, Vol.34 (1), p.e14178-n/a
Hauptverfasser: Heitmann, Paul T., Mohd Rosli, Reizal, Maslen, Lyn, Wiklendt, Lukasz, Kumar, Raghu, Omari, Taher I., Wattchow, David, Costa, Marcello, Brookes, Simon J., Dinning, Phil G.
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Sprache:eng
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Zusammenfassung:Background The colonic motor patterns associated with gas transit are poorly understood. This study describes the application of high‐resolution impedance manometry (HRiM) in the human colon in vivo to characterize distal colonic motility and gas transit; (a) after a meal and (b) after intraluminal gas insufflation into the sigmoid colon. Methods HRiM recordings were performed in 19 healthy volunteers, with sensors positioned from the distal descending colon to the proximal rectum. Protocol 1 (n = 10) compared pressure and impedance prior to and after a meal. Protocol 2 (n = 9) compared pressure and impedance before and after gas insufflation into the sigmoid colon (60 mL total volume). Key Results Both the meal and gas insufflation resulted in an increase in the prevalence of the 2‐8/minute “cyclic motor pattern” (meal: (t(9) = −6.42, P
ISSN:1350-1925
1365-2982
DOI:10.1111/nmo.14178