High‐resolution impedance manometry characterizes the functional role of distal colonic motility in gas transit
Background The colonic motor patterns associated with gas transit are poorly understood. This study describes the application of high‐resolution impedance manometry (HRiM) in the human colon in vivo to characterize distal colonic motility and gas transit; (a) after a meal and (b) after intraluminal...
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Veröffentlicht in: | Neurogastroenterology and motility 2022-01, Vol.34 (1), p.e14178-n/a |
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Sprache: | eng |
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Zusammenfassung: | Background
The colonic motor patterns associated with gas transit are poorly understood. This study describes the application of high‐resolution impedance manometry (HRiM) in the human colon in vivo to characterize distal colonic motility and gas transit; (a) after a meal and (b) after intraluminal gas insufflation into the sigmoid colon.
Methods
HRiM recordings were performed in 19 healthy volunteers, with sensors positioned from the distal descending colon to the proximal rectum. Protocol 1 (n = 10) compared pressure and impedance prior to and after a meal. Protocol 2 (n = 9) compared pressure and impedance before and after gas insufflation into the sigmoid colon (60 mL total volume).
Key Results
Both the meal and gas insufflation resulted in an increase in the prevalence of the 2‐8/minute “cyclic motor pattern” (meal: (t(9) = −6.42, P |
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ISSN: | 1350-1925 1365-2982 |
DOI: | 10.1111/nmo.14178 |