Two-photon fluorescence and MR bio-imaging of endogenous H2O2 in the tumor microenvironment using a dual-mode nanoprobe

Two-photon fluorescence and MR bio-imaging of endogenous H2O2 in the tumor microenvironment using a dual-mode nanoprobe

The dual-mode bio-imaging nanoprobe TP-CQDs@MnO2, based on two-photon carbon quantum dots and MnO2, has been developed for the two-photon fluorescence and MR imaging of endogenous H2O2 in the tumor microenvironment, and it achieved high selectivity, a great signal-to-noise ratio, a limit of detectio...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2021-06, Vol.57 (51), p.6288-6291
Hauptverfasser: Zhong, Hongmei, Yu, Shengrong, Li, Bingqian, He, Kangdi, Li, Dian, Wang, Xiao, Yong-Xiang, Wu
Format: Artikel
Sprache:eng
Schlagworte:
Fluorescence
Hydrogen peroxide
Magnetic resonance imaging
Manganese dioxide
Penetration depth
Photons
Quantum dots
Selectivity
Signal to noise ratio
Tumors
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Beschreibung
Zusammenfassung:The dual-mode bio-imaging nanoprobe TP-CQDs@MnO2, based on two-photon carbon quantum dots and MnO2, has been developed for the two-photon fluorescence and MR imaging of endogenous H2O2 in the tumor microenvironment, and it achieved high selectivity, a great signal-to-noise ratio, a limit of detection (LOD) of 1.425 pM for H2O2, and a two-photon tissue penetration depth of 280 μm.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc01129d