TANK-binding kinase 1 (TBK1): An emerging therapeutic target for drug discovery

[Display omitted] •TBK1 has attracted the interest of researchers as an emerging therapeutic target.•Significant efforts were devoted to develop specific TBK1 inhibitors. Dysregulation of TANK-binding kinase 1 (TBK1) homeostasis leads to the occurrence and progression of many diseases, such as inflammation, autoimmune diseases, metabolic diseases, and cancer. Therefore, there is a need to develop TBK1 inhibitors as therapeutic agents. In this review, we highlight the diverse biological functions of TBK1 and summarize the promising small-molecule inhibitors of TBK1 that have the potential to be developed as therapeutic candidates.