Growth of Mesenchymal Stem Cells on Poly(3-Hydroxybutyrate) Scaffolds Loaded with Simvastatin

Growth of Mesenchymal Stem Cells on Poly(3-Hydroxybutyrate) Scaffolds Loaded with Simvastatin

We studied the effect of porous composite scaffolds based on poly(3-hydroxybutyrate) (PHB) loaded with simvastatin on the growth and differentiation of mesenchymal stem cells. The scaffolds have a suitable microstructure (porosity and pore size) and physicochemical properties to support the growth o...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2021-05, Vol.171 (1), p.172-177, Article 172
Hauptverfasser: Akoulina, E. A., Demianova, I. V., Zharkova, I. I., Voinova, V. V., Zhuikov, V. A., Khaydapova, D. D., Chesnokova, D. V., Menshikh, K. A., Dudun, A. A., Makhina, T. K., Bonartseva, G. A., Volkov, A. V., Asfarov, T. F., Ivanov, S. Y., Shaitan, K. V., Bonartsev, A. P.
Format: Artikel
Sprache:eng
Schlagworte:
3-Hydroxybutyric Acid - pharmacology
Alkaline phosphatase
Antilipemic agents
Biomedical and Life Sciences
Biomedicine
Biopolymers
Cell Biology
Cell Differentiation
Growth
Hydroxybutyrates
Internal Medicine
Laboratory Medicine
Mesenchymal Stem Cells
Osteogenesis
Pathology
Phosphatases
Physicochemical properties
Polyesters
Porosity
Simvastatin
Simvastatin - pharmacology
Stem cells
Tissue Engineering
Tissue Scaffolds - chemistry
Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
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Zusammenfassung:We studied the effect of porous composite scaffolds based on poly(3-hydroxybutyrate) (PHB) loaded with simvastatin on the growth and differentiation of mesenchymal stem cells. The scaffolds have a suitable microstructure (porosity and pore size) and physicochemical properties to support the growth of mesenchymal stem cells. Scaffold loading with simvastatin suppressed cell growth and increased alkaline phosphatase activity, which can attest to their osteoinductive properties.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-021-05190-8