On the Mechanism of Cardioprotective Effect of Fabomotizole in Alcoholic Cardiomyopathy

The molecular mechanisms underlying the cardioprotective effect of fabomotizole were studied using the translational rat model of alcoholic cardiomyopathy developed by us. It was shown that intraperitoneal administration of fabomotizole (15 mg/kg) for 28 days to animals with alcoholic cardiomyopathy...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2021-05, Vol.171 (1), p.41-44
Hauptverfasser:	Kryzhanovskii, S. A., Kozhevnikova, L. M., Vititnova, M. B., Efimova, A. O., Stolyaruk, V. N., Tsorin, I. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Biomedical and Life Sciences Biomedicine Cardiomyopathy Cardiomyopathy, Alcoholic - drug therapy Cardiomyopathy, Alcoholic - metabolism Cell Biology Gene expression Heart diseases Heart Ventricles - metabolism Internal Medicine Laboratory Medicine Molecular modelling mRNA Myocardium Myocardium - metabolism Pathology Proteins Rats Regulatory proteins RNA RNA, Messenger - metabolism Ryanodine Receptor Calcium Release Channel - metabolism Ryanodine receptors Ventricle
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Zusammenfassung:	The molecular mechanisms underlying the cardioprotective effect of fabomotizole were studied using the translational rat model of alcoholic cardiomyopathy developed by us. It was shown that intraperitoneal administration of fabomotizole (15 mg/kg) for 28 days to animals with alcoholic cardiomyopathy contributes to normalization of the expression of mRNA of genes of regulatory proteins СаМ ( p =0.00001), Ерас1 ( p =0.021), and Ерас2 ( p =0.018) and receptors RyR2 ( p =0.0031) and IP3R2 ( p =0.006) in the myocardium of the myocardium of the left ventricle that is enhanced in control animals ( p
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-021-05168-6