A Biomarker for Benign Adult Familial Myoclonus Epilepsy: High‐Frequency Activities in Giant Somatosensory Evoked Potentials

Background Benign adult familial myoclonus epilepsy (BAFME) is one of the diseases that cause cortical myoclonus (CM) with giant somatosensory evoked potentials (SEPs). There are no useful diagnostic biomarkers differentiating BAFME from other CM diseases. Objective To establish reliable biomarkers including high‐frequency oscillations (HFOs) with giant SEPs for the diagnosis of BAFME. Methods This retrospective case study included 49 consecutive CM patients (16 BAFME and 33 other CM patients) who exhibited giant P25 or N35 SEPs. SEPs were processed by a band‐pass filter of 400–1000 Hz to analyze HFOs. Clinical and SEP findings were compared between (1) BAFME and other CM groups and (2) patients with presence and absence of P25‐HFOs (HFOs superimposed on giant P25). The diagnostic power of each factor for BAFME was calculated. Results All 16 BAFME patients showed SEP P25‐HFOs with significantly higher occurrence (P