Downregulation of Serum and Distal Ileum Fibroblast Growth Factor19 in Bile Acid Diarrhoea Patients

Background Bile acid diarrhoea or BAD is a common but little recognised cause of chronic diarrhoea. Few of these patients in China have been diagnosed due to a lack of diagnostic options. Aims To clarify the diagnostic value of serum fibroblast growth factor19 (FGF19) in BAD patients. Methods We rep...

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Veröffentlicht in:	Digestive diseases and sciences 2022-03, Vol.67 (3), p.872-879
Hauptverfasser:	Chang, Chunxia, Jiang, Jingjing, Sun, Rui, Wang, Shenggen, Chen, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Analysis Bile Bile acids Bile Acids and Salts Biochemistry Diarrhea Diarrhea - etiology Down-Regulation Enzymes Fibroblast growth factors Fibroblast Growth Factors - metabolism Fibroblasts Fibroblasts - metabolism Gastroenterology Hepatology Hospitals Humans Ileum - metabolism Medical colleges Medicine Medicine & Public Health Metabolism Oncology Original Article Pathophysiology Proteins Small intestine Transplant Surgery
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Zusammenfassung:	Background Bile acid diarrhoea or BAD is a common but little recognised cause of chronic diarrhoea. Few of these patients in China have been diagnosed due to a lack of diagnostic options. Aims To clarify the diagnostic value of serum fibroblast growth factor19 (FGF19) in BAD patients. Methods We reported on 60 chronic diarrhoea patients and 80 healthy volunteers (HV). Based on the 90th percentile levels of serum 7a-hydroxy-4-cholesten-3-one (C4) of HV, these patients were divided into BAD group (C4 ≥ 90th) and non-bile acid diarrhoea group (NBAD, C4
ISSN:	0163-2116 1573-2568
DOI:	10.1007/s10620-021-07042-x