GAB1‐ABL1 fusions in tumors that have histologic overlap with NTRK‐rearranged spindle cell tumors

Fibroblastic spindle cell tumors are a heterogeneous group of rare soft tissue tumors that are increasingly recognized as associated with a variety of kinase gene fusions. We report two cases of GAB1‐ABL1 fusions in spindle cell tumors that histologically overlap with neurotrophic tyrosine receptor...

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Veröffentlicht in:	Genes chromosomes & cancer 2021-09, Vol.60 (9), p.623-630
Hauptverfasser:	Choo, Florence, Rakheja, Dinesh, Davis, Lara E., Davare, Monika, Park, Jason Y., Timmons, Charles F., Neff, Tanaya, Beadling, Carol, Corless, Christopher L., Davis, Jessica L.
Format:	Artikel
Sprache:	eng
Schlagworte:	ABL1 Abl1 gene Adaptor Proteins, Signal Transducing - genetics Aged Antigens, CD34 - genetics Antigens, CD34 - metabolism Carcinoma - genetics Carcinoma - pathology CD34 CD34 antigen Child Collagen Female Humans Imatinib Mitosis NTRK Oncogene Proteins, Fusion - genetics Proto-Oncogene Proteins c-abl - genetics Receptor, trkC - genetics S100 S100 Proteins - genetics S100 Proteins - metabolism Sarcoma Soft Tissue Neoplasms - genetics Soft Tissue Neoplasms - pathology Targeted cancer therapy Transcriptomes Tumors Tyrosine
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Zusammenfassung:	Fibroblastic spindle cell tumors are a heterogeneous group of rare soft tissue tumors that are increasingly recognized as associated with a variety of kinase gene fusions. We report two cases of GAB1‐ABL1 fusions in spindle cell tumors that histologically overlap with neurotrophic tyrosine receptor kinase (NTRK)‐rearranged spindle cell tumors. The first case occurred in a 76‐year‐old female who had a large deep‐seated spindle cell tumor composed of monotonous ovoid to spindle cells in a background of thick stromal collagen bands with prominent hyalinized vessels and inconspicuous mitoses (
ISSN:	1045-2257 1098-2264
DOI:	10.1002/gcc.22972