Complement-in’ the germinal center response

B cells rewire complement for optimal germinal center responses. When B cell C3 activity is limited, germinal centers collapse and outputs are impaired.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature immunology 2021-06, Vol.22 (6), p.673-674
Hauptverfasser:	Robinson, Marcus James, Quast, Isaak, Tarlinton, David Mathew
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/40/2508 631/250/2152/2153/1982 631/250/2501 B cells Biomedical and Life Sciences Biomedicine Complement (Immunology) Complement component C3 Germinal centers Health aspects Immune response Immunological research Immunology Infectious Diseases Lymphocytes B Lymphoid tissue News & Views news-and-views Physiological aspects T cells
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Beschreibung
Zusammenfassung:	B cells rewire complement for optimal germinal center responses. When B cell C3 activity is limited, germinal centers collapse and outputs are impaired.
ISSN:	1529-2908 1529-2916
DOI:	10.1038/s41590-021-00946-w