Total Synthesis of (−)-Disorazole C1

Total Synthesis of (−)-Disorazole C1

Disorazoles represent a powerful class of highly potent antitubulin natural products isolated from myxobacteria. Herein, we describe a scalable and robust synthesis of (−)-disorazole C1 with high stereoselectivity, featuring quite simple reaction conditions that can be used to produce large quantiti...

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Veröffentlicht in:Organic letters 2021-06, Vol.23 (12), p.4543-4547
Hauptverfasser: Lizzadro, Luca, Spieß, Oliver, Schinzer, Dieter
Format: Artikel
Sprache:eng
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Zusammenfassung:Disorazoles represent a powerful class of highly potent antitubulin natural products isolated from myxobacteria. Herein, we describe a scalable and robust synthesis of (−)-disorazole C1 with high stereoselectivity, featuring quite simple reaction conditions that can be used to produce large quantities of this remarkable biologically active compound.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c01123