Indium‐Catalyzed C‐F Bond Transformation through Oxymetalation/β‐Fluorine Elimination to Access Fluorinated Isocoumarins

Invited for the cover of this issue are Yoshihiro Nishimoto, Makoto Yasuda and co‐workers at Osaka University and MOLSIS Inc.. The image depicts the crafting of a gladiator's shield to represent the reaction reported in this work. Read the full text of the article at 10.1002/chem.202100672. “Th...

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Veröffentlicht in:Chemistry : a European journal 2021-06, Vol.27 (32), p.8232-8232
Hauptverfasser: Yata, Tetsuji, Nishimoto, Yoshihiro, Chiba, Kouji, Yasuda, Makoto
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Sprache:eng
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Zusammenfassung:Invited for the cover of this issue are Yoshihiro Nishimoto, Makoto Yasuda and co‐workers at Osaka University and MOLSIS Inc.. The image depicts the crafting of a gladiator's shield to represent the reaction reported in this work. Read the full text of the article at 10.1002/chem.202100672. “The DFT calculation results revealed an attractive characteristic of indium atoms with fluorine atoms. These significant results show that indium salts act as a π‐Lewis activator of gem‐difluoroalkene and smoothly fluoride thanks to an affinity toward fluorine atoms. In indium chemistry, few results of C−F bond functionalization have been established. We achieved both indium‐catalyzed C−F bond functionalization and the first synthesis of monofluorinated isocoumarin at the 3‐position.” Read more about the story behind the cover in the Cover Profile and about the research itself on page 8288 ff. (DOI: 10.1002/chem.202100672).
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202101570