Inflammation can increase hepcidin in HFE-hereditary hemochromatosis

Inflammation can increase hepcidin in HFE-hereditary hemochromatosis

We present a p.C282Y homozygous patient with high hepcidin levels and normal iron parameters during systemic inflammation. This suggests that in the absence of a proper functioning HFE, resulting in blockage of the BMP/SMAD pathway, the innate low hepcidin concentration can be upregulated by inflamm...

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Veröffentlicht in:Clinical case reports 2021, Vol.9 (5), p.e04114-e04114
Hauptverfasser: Moris, Wenke, Verhaegh, Pauline L M, Masclee, Ad A M, Swinkels, Dorine W, Laarakkers, Coby M, Koek, Ger H, van Deursen, Cees Th B M
Format: Report
Sprache:eng
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Zusammenfassung:We present a p.C282Y homozygous patient with high hepcidin levels and normal iron parameters during systemic inflammation. This suggests that in the absence of a proper functioning HFE, resulting in blockage of the BMP/SMAD pathway, the innate low hepcidin concentration can be upregulated by inflammation, probably via the JAK/STAT3 pathway.
ISSN:2050-0904
2050-0904
DOI:10.1002/ccr3.4114