Circulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients

Circulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins were measured in longitudinal plasma samples collected from 13 participants who received two doses of mRNA-1273 vaccine. Eleven of 13 participants showed detectable levels of SARS-CoV-2 protein as early as day 1 after fir...

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Veröffentlicht in:Clinical infectious diseases 2022-03, Vol.74 (4), p.715-718
Hauptverfasser: Ogata, Alana F, Cheng, Chi-An, Desjardins, Michaël, Senussi, Yasmeen, Sherman, Amy C, Powell, Megan, Novack, Lewis, Von, Salena, Li, Xiaofang, Baden, Lindsey R, Walt, David R
Format: Artikel
Sprache:eng
Schlagworte:
2019-nCoV Vaccine mRNA-1273
Antibodies, Viral
COVID-19 - prevention & control
COVID-19 Vaccines
Humans
Immunoglobulin A
SARS-CoV-2 - genetics
Spike Glycoprotein, Coronavirus - blood
Spike Glycoprotein, Coronavirus - genetics
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Zusammenfassung:Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins were measured in longitudinal plasma samples collected from 13 participants who received two doses of mRNA-1273 vaccine. Eleven of 13 participants showed detectable levels of SARS-CoV-2 protein as early as day 1 after first vaccine injection. Clearance of detectable SARS-CoV-2 protein correlated with production of immunoglobulin G (IgG) and immunoglobulin A (IgA).
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciab465