Association of kidney functions with a cascade of care for diabetes and hypertension in two geographically distinct Indian cohorts

•We determined care cascade of T2DM & HTN in the North and South Indian cohorts.•The South Indian cohort had a better care cascade for CKD-risk factors, T2DM & HTN.•Similar low-eGFR proportion, despite less cases with T2DM & HTN in north cohort.•Younger participants with mild-to-moderate low eGFR were prevalent in North cohort.•Care cascade of T2DM and HTN were associated with lower CVD risk, BUN and optimal eGFR. Type 2 diabetes (T2DM) and hypertension (HTN) are the main modifiable risk factors of chronic kidney disease (CKD), among the known traditional and non-traditional risk factors. We determined the prevalence and care-cascade of these modifiable CKD-risk factors and their association with socioeconomic status in adjoining Lucknow and Puducherry cities of India. 439 participants reported no CKD were recruited. Serum analysis revealed an Estimated Glomerular Filtration Rate (eGFR) ≥ 90 ml/min/1.73 m2 in 60.36% of the population. Of them, 55.85% had HTN and/or T2DM as CKD-risk factors; however, less than half of this population was unaware of their CKD-risk status. Awareness and treatment were significantly higher in Puducherry and were associated with literacy, occupation, and residence place. Although the CKD-risk population was about two times higher in Puducherry than Lucknow, the populations with mild-low eGFR were comparable in the two regions. Moreover, in Lucknow, mild-low eGFR and low awareness were more prevalent among the younger participants (