HLA‐DRB115:01 is a co‐receptor for Epstein–Barr virus, linking genetic and environmental risk factors for multiple sclerosis

HLA‐DRB115:01 is a co‐receptor for Epstein–Barr virus, linking genetic and environmental risk factors for multiple sclerosis

The strongest genetic and environmental risk factors for MS, an inflammatory CNS disease, are HLA‐DRB1*15:01 and EBV. This work shows that HLA‐DRB1*15:01 acts as a co‐receptor for EBV infection of a B cell line, suggesting a mechanistic link between both risk factors for MS.

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Veröffentlicht in:European journal of immunology 2021-09, Vol.51 (9), p.2348-2350
Hauptverfasser: Menegatti, Jennifer, Schub, David, Schäfer, Marco, Grässer, Friedrich A., Ruprecht, Klemens
Format: Artikel
Sprache:eng
Schlagworte:
Drb1 protein
Epstein-Barr virus
Histocompatibility antigen HLA
HLA‐DRB115:01
human leukocyte antigen
Multiple sclerosis
receptor
Risk factors
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Zusammenfassung:The strongest genetic and environmental risk factors for MS, an inflammatory CNS disease, are HLA‐DRB1*15:01 and EBV. This work shows that HLA‐DRB1*15:01 acts as a co‐receptor for EBV infection of a B cell line, suggesting a mechanistic link between both risk factors for MS.
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.202149179