18 F-FDG PET/CT use in functional assessment of the testes: A systematic review

Our study analysed previous studies employing positron emission tomography with co-registered computer tomography (PET/CT) in andrological patient evaluation and assessed the differences in 2-[ F]F-fluoro-2'-deoxyglucose (FDG) uptake between three groups: healthy testes, benign and malignant testicular pathology. Medline and Embase were systematically searched for studies involving FDG-PET/CT imaging of testes with results expressed as mean standardised uptake value (SUV ). A one-way ANOVA was used to compare SUV between three groups. All papers assessing andrological parameters were pooled to compare fertility data. Seventeen studies, including three relating to fertility diagnosis, with a total of 830 patients, were included in the review. One-way ANOVA showed a statistical difference between mean values of tracer SUV in healthy and malignant testes (Dif. = -2.77, 95% CI = -4.32 to 1.21, p