Reduced alternative insulin dosing in hyperkalemia: A meta‐analysis of effects on hypoglycemia and potassium reduction

Study Objective Recent studies have identified that reduced alternative intravenous insulin doses, such as 5 units or 0.1 units/kg, may reduce the risk of hypoglycemia compared to standard doses of 10 units in patients treated for hyperkalemia. However, some studies suggest that these alternative do...

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Veröffentlicht in:Pharmacotherapy 2021-07, Vol.41 (7), p.598-607
Hauptverfasser: Moussavi, Kayvan, Garcia, Joshua, Tellez‐Corrales, Eglis, Fitter, Scott
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Sprache:eng
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Zusammenfassung:Study Objective Recent studies have identified that reduced alternative intravenous insulin doses, such as 5 units or 0.1 units/kg, may reduce the risk of hypoglycemia compared to standard doses of 10 units in patients treated for hyperkalemia. However, some studies suggest that these alternative doses may reduce the ability to lower serum potassium. This study was performed to determine the impact of alternative insulin dosing on hypoglycemia and potassium reduction in patients with hyperkalemia. Design Meta‐analysis. Data Source PubMed/MEDLINE, CENTRAL, Ovid, and ClinicalTrials.gov were searched from inception through November 2020. Patients Patients treated with standard (10 units) or alternative (
ISSN:0277-0008
1875-9114
DOI:10.1002/phar.2596