Pragmatic Trials — Need for ADAPTABLE Design

The publication in the Journal of the results of ADAPTABLE (Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-Term Effectiveness) 1 comparing two doses of aspirin for the secondary prevention of cardiovascular disease represents a major step forward in establishing the pragmatic trial as an investigatory tool in the United States. The authors used a range of innovative and low-cost methods to simplify the identification, recruitment, and follow-up of patients: for example, algorithms were used to interrogate electronic health record data to identify eligible patients within the National Patient-Centered Clinical Research Network (PCORnet); patients could access a Web portal to give . . .