Four new xanthones and their cytotoxicity from the stems of Garcinia schomburgkiana

Four new xanthones and their cytotoxicity from the stems of Garcinia schomburgkiana

Four new xanthones, named schomburgones C - F ( 1‒4 ), along with six known xanthones ( 5‒10 ) were isolated from the stems of Garcinia schomburgkiana . Their structures were determined by spectroscopic analysis especially 1D and 2D NMR spectroscopies. The isolated compounds were evaluated for their...

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Veröffentlicht in:Journal of natural medicines 2021-09, Vol.75 (4), p.871-876
Hauptverfasser: Kaennakam, Sutin, Sukandar, Edwin Risky, Juntagoot, Thanawan, Siripong, Pongpun, Tip-pyang, Santi
Format: Artikel
Sprache:eng
Schlagworte:
Biological products
Biomedical and Life Sciences
Biomedicine
Complementary & Alternative Medicine
Cytotoxicity
Flowers & plants
Garcinia
Medicinal Chemistry
NMR
Nuclear magnetic resonance
Original Paper
Pharmacology/Toxicology
Pharmacy
Phytochemicals
Plant Sciences
Tumor cell lines
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Zusammenfassung:Four new xanthones, named schomburgones C - F ( 1‒4 ), along with six known xanthones ( 5‒10 ) were isolated from the stems of Garcinia schomburgkiana . Their structures were determined by spectroscopic analysis especially 1D and 2D NMR spectroscopies. The isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines. Furanoxanthones 4‒6 showed potent cytotoxicity against four cell lines (KB, HeLa S3, MCF-7 and Hep G2) with IC 50 values in the range of 0.18‒9.95  µ M. Graphic abstract
ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-021-01527-9