Multiple organ failure might be an indication for prophylactic antifungal therapy in acute pancreatitis

Multiple organ failure might be an indication for prophylactic antifungal therapy in acute pancreatitis

Purpose Significant conflicts regarding prophylactic antifungal treatment in acute pancreatitis (AP) exist among current literatures and guidelines. The key to resolving this controversial issue is to identify risk factors for intra-abdominal fungal infection (AFI) among patients with AP. Methods A...

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Veröffentlicht in:Infection 2021-08, Vol.49 (4), p.769-774
Hauptverfasser: Ning, Caihong, Zhu, Shuai, Zhou, Shuyi, Lin, Chiayen, Li, Jiarong, Cao, Xintong, Bonsu, Abdul Aziz F. K., Shen, Dingcheng, Liu, Zhiyong, Huang, Gengwen
Format: Artikel
Sprache:eng
Schlagworte:
Antifungal agents
Brief Report
Failure
Family Medicine
Fungicides
General Practice
Indication
Infectious Diseases
Internal Medicine
Medicine
Medicine & Public Health
Multiple organ dysfunction syndrome
Pancreatitis
Patients
Risk analysis
Risk factors
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Zusammenfassung:Purpose Significant conflicts regarding prophylactic antifungal treatment in acute pancreatitis (AP) exist among current literatures and guidelines. The key to resolving this controversial issue is to identify risk factors for intra-abdominal fungal infection (AFI) among patients with AP. Methods A single-center, retrospective cohort of 826 patients with AP between January 2014 to December 2019 was analysed to study the risk factors of AFI. Results Of the 826 patients with AP, 10 patients (1.2%) developed AFI, including 2 cases in moderately severe AP (MSAP) and 8 in severe AP (SAP). The incidence of AFI was significantly higher in patients with SAP compared with MSAP and mild AP (10.3 vs. 0.8% vs. 0, P  
ISSN:0300-8126
1439-0973
DOI:10.1007/s15010-021-01625-6