Body Composition in Patients With Psoriatic Arthritis and Changes During Interleukin‐12/Interleukin‐23 Inhibition

Objective Little is known about body composition in patients with psoriatic arthritis (PsA). Our objective was to compare body composition parameters in PsA patients and healthy controls and then investigate the effects of ustekinumab (UST) on body composition in patients with PsA. Methods At baseline, 30 PsA patients were compared cross‐sectionally with 60 healthy controls without PsA, matched for age, sex, menopausal status, and body mass index (BMI). Thirty active PsA patients treated with UST were included in a 6‐month open follow‐up study. Body composition parameters were measured at baseline and 6 months of treatment. Results Body composition parameters were different in PsA patients compared to healthy controls; in PsA patients, total and appendicular lean mass were lower (P = 0.013 and P = 0.010, respectively), whereas total fat mass was higher (P