Targeting the TGF-β signaling pathway for resolution of pulmonary arterial hypertension

Aberrant transforming growth factor-β (TGF-β) signaling activation is linked to pulmonary arterial hypertension (PAH). BMPR2 mutations perturb the balance between bone morphogenetic protein (BMP) and TGF-β pathways, leading to vascular remodeling, narrowing of the lumen of pulmonary vasculature, and...

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Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 2021-07, Vol.42 (7), p.510-513
Hauptverfasser:	Sharmin, Nahid, Nganwuchu, Chinyere Chioma, Nasim, Md Talat
Format:	Artikel
Sprache:	eng
Schlagworte:	ALK5 inhibitor BMP pulmonary arterial hypertension pulmonary vasculature TGF-β
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description	Aberrant transforming growth factor-β (TGF-β) signaling activation is linked to pulmonary arterial hypertension (PAH). BMPR2 mutations perturb the balance between bone morphogenetic protein (BMP) and TGF-β pathways, leading to vascular remodeling, narrowing of the lumen of pulmonary vasculature, and clinical symptoms. This forum highlights the association of the TGF-β pathway with pathogenesis and therapeutic approaches.
doi_str_mv	10.1016/j.tips.2021.04.002
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subjects	ALK5 inhibitor BMP pulmonary arterial hypertension pulmonary vasculature TGF-β
title	Targeting the TGF-β signaling pathway for resolution of pulmonary arterial hypertension
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