Targeting the TGF-β signaling pathway for resolution of pulmonary arterial hypertension

Targeting the TGF-β signaling pathway for resolution of pulmonary arterial hypertension

Aberrant transforming growth factor-β (TGF-β) signaling activation is linked to pulmonary arterial hypertension (PAH). BMPR2 mutations perturb the balance between bone morphogenetic protein (BMP) and TGF-β pathways, leading to vascular remodeling, narrowing of the lumen of pulmonary vasculature, and...

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Veröffentlicht in:Trends in pharmacological sciences (Regular ed.) 2021-07, Vol.42 (7), p.510-513
Hauptverfasser: Sharmin, Nahid, Nganwuchu, Chinyere Chioma, Nasim, Md Talat
Format: Artikel
Sprache:eng
Schlagworte:
ALK5 inhibitor
BMP
pulmonary arterial hypertension
pulmonary vasculature
TGF-β
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Zusammenfassung:Aberrant transforming growth factor-β (TGF-β) signaling activation is linked to pulmonary arterial hypertension (PAH). BMPR2 mutations perturb the balance between bone morphogenetic protein (BMP) and TGF-β pathways, leading to vascular remodeling, narrowing of the lumen of pulmonary vasculature, and clinical symptoms. This forum highlights the association of the TGF-β pathway with pathogenesis and therapeutic approaches.
ISSN:0165-6147
1873-3735
DOI:10.1016/j.tips.2021.04.002