Sodium metabisulfite as a cytotoxic food additive induces apoptosis in HFFF2 cells

Sodium metabisulfite as a cytotoxic food additive induces apoptosis in HFFF2 cells

•Cytotoxic effects of SMB were investigated on HFFF2 cells.•SMB reduced cell viability and induced apoptosis.•SMB modulated the expression of genes involved in apoptosis pathways.•This food additive increased ROS levels and activated autophagy. Sodium metabisulfite (SMB), an antioxidant agent, is ex...

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Veröffentlicht in:Food chemistry 2021-10, Vol.358, p.129910-129910, Article 129910
Hauptverfasser: Alimohammadi, Afshin, Moosavy, Mir-Hassan, Amin Doustvandi, Mohammad, Baradaran, Behzad, Amini, Mohammad, Mokhtarzadeh, Ahad, de la Guardia, Miguel
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Autophagy
Cytotoxicity
Food safety
Oxidative stress
Sodium Metabisulfite
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Zusammenfassung:•Cytotoxic effects of SMB were investigated on HFFF2 cells.•SMB reduced cell viability and induced apoptosis.•SMB modulated the expression of genes involved in apoptosis pathways.•This food additive increased ROS levels and activated autophagy. Sodium metabisulfite (SMB), an antioxidant agent, is extensively used as a preservative in food industry. The current study was aimed to clarify its potential toxic effects on human fetal foreskin fibroblasts (HFFF2) cells, in vitro. Subsequently, MTT results illustrated that exposure to SMB significantly (p 
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2021.129910