On location for cannabinoid control of multimodal behavior

In this issue of Neuron, Soria-Gomez et al. (2021) investigate whether activation of the type 1 cannabinoid receptor at specific subcellular locations within a single neural circuit produces multimodal behavior. Their results demonstrate that location matters: striatonigral mitochondrial CB1 drives...

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Veröffentlicht in:Neuron (Cambridge, Mass.) Mass.), 2021-05, Vol.109 (9), p.1416-1418
Hauptverfasser: McKeon, Paige N, Mathur, Brian N
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description In this issue of Neuron, Soria-Gomez et al. (2021) investigate whether activation of the type 1 cannabinoid receptor at specific subcellular locations within a single neural circuit produces multimodal behavior. Their results demonstrate that location matters: striatonigral mitochondrial CB1 drives catalepsy while striatonigral plasma membrane CB1 receptors enable antinociception.
doi_str_mv 10.1016/j.neuron.2021.04.013
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subjects Behavior
Cannabinoid CB1 receptors
Catalepsy
Kinases
Mitochondria
Pain
Pain perception
Plasma
Tetrahydrocannabinol
THC
title On location for cannabinoid control of multimodal behavior
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