An Older Subjective Age Is Related to Accelerated Epigenetic Aging

An Older Subjective Age Is Related to Accelerated Epigenetic Aging

The present study examined the prospective association between subjective age and epigenetic clock in 2,253 adults (Mean age = 67.40, SD = 8.17) from the Health and Retirement Study. Subjective age and demographic factors were assessed in 2008/2010 and epigenetic clock was assessed in 2016 using the...

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Veröffentlicht in:Psychology and aging 2021-09, Vol.36 (6), p.767-772
Hauptverfasser: Stephan, Yannick, Sutin, Angelina R., Luchetti, Martina, Terracciano, Antonio
Format: Artikel
Sprache:eng
Schlagworte:
Age
Aging
Chronological Age
Demography
Deoxyribonucleic acid
DNA
DNA methylation
Epigenetics
Female
Health status
Human
Inflammation
Male
Retirement
Self evaluation
Subjective age
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Zusammenfassung:The present study examined the prospective association between subjective age and epigenetic clock in 2,253 adults (Mean age = 67.40, SD = 8.17) from the Health and Retirement Study. Subjective age and demographic factors were assessed in 2008/2010 and epigenetic clock was assessed in 2016 using the DNA methylation (DNAm) PhenoAge. Regression analysis revealed that an older subjective age was associated with accelerated epigenetic aging; mediation analysis revealed that self-rated health and CRP accounted for this association. The findings indicate that individuals who feel older than their chronological age are biologically older, in part because of their perceived health and inflammatory profiles.
ISSN:0882-7974
1939-1498
DOI:10.1037/pag0000607